HLA-DQA2
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Official Full Name
major histocompatibility complex, class II, DQ alpha 2 -
Overview
This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. -
Synonyms
HLA-DQA2;major histocompatibility complex, class II, DQ alpha 2;HLA DXA;HLA class II histocompatibility antigen, DQ alpha 2 chain;HLA-DQA1;DX alpha chain;MHC class II DQA2;HLA class II histocompatibility antigen, DQ(6) alpha chain;HLA-DXA;DX-ALPH
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DQA2-5494HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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| HLA-DQA2-1279H | Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged | E.coli | Human | His | 24-214 aa |
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| RFL35265HF | Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dq Alpha 2 Chain(Hla-Dqa2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (24-255) |
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Involved Pathway
HLA-DQA2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA2 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leishmaniasis | HLA-DRB5,RELA,IRAK1,HLA-DRB1,TLR4,NCF4,FCGR3A,MAPK11,IFNGR2,NCF2 |
| Systemic lupus erythematosus | HIST1H4I,GM14483,HIST1H2AK,CD40LG,HIST1H4D,GM14477,HIST1H4H,C8B,HIST1H4L,SNRPB |
| Viral myocarditis | CYCS,HLA-DPA1,HLA-DRB4,CAV1,CD86,RAC2,ITGAL,BID,SGCA,HLA-DOB |
| ne network for IgA production | HLA-DRB4,CCL25,MHC2DEB,MHC2DAB,CCR10,CD80,ITGB7,TNFRSF17,Il2,H2-AA |
| Antigen processing and presentation | HSPA8,HSPA1A,RFXANK,RFXAP,CTSS,B2M,KIR2DL4,HLA-B,HLA-F,CTSB |
| Epstein-Barr virus infection | RELA,SPI1,POLR2B,PSMC1,EIF2AK3,TRP53,GTF2E2,HLA-DRB4,CD19,CD38 |
| Herpes simplex infection | PVRL2,SRSF1A,TAF9B,IRF7,ARNTL1A,MAPK8A,HLA-DOA,HLA-DPB1,TTC6,HLA-C |
| Autoi | IFNA12,HLA-DRB5,HLA-DQB1,IFNA6,IFNA1,TPO,HLA-DOA,GZMB,CD80,HLA-G |
| Cell adhesion molecules (CAMs) | CLDN17,CD8B,SELL,ITGA9,CLDND,BF2,ITGA6,CLDN7B,NRCAMA,PVR |
Protein Function
HLA-DQA2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA2 itself. We selected most functions HLA-DQA2 had, and list some proteins which have the same functions with HLA-DQA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II receptor activity | HLA-DOA,HLA-DRB1,HLA-DRA,HLA-DPA1,KRT17,HLA-DQA1,HLA-DRB4,HLA-DOB,HLA-DQB1,HLA-DRB3 |
Interacting Protein
HLA-DQA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA2.
Resources
Research Area
Mesenchymal Stem Cell MarkersMesodermal Lineage Markers
Dendritic Cell Co-stimulatory Molecules
Related Services
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References
- Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).
