HLA-DPA1
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Official Full Name
major histocompatibility complex, class II, DP alpha 1 -
Overview
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. -
Synonyms
T1;HLADP;HLASB;HLA-DP1A;HLA-DPA1;HLA class II histocompatibility antigen, DP alpha 1 chain;DP(W3);DP(W4);MHC class II DPA;HLA-SB alpha chain;OTTHUMP00000029066;MHC class II antigen;MHC class II DP3-alpha;Primed lymphocyte test-4;MHC class IIPA1 antigen;HLA class II histocompatibility antigen, DP alpha chain
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-DPA1-13816H | Recombinant Human HLA-DPA1, GST-tagged | E.coli | Human | GST | 32-224a.a. | |
| HLA-DPA1-3427H | Recombinant Human HLA-DPA1 protein, His-tagged | E.coli | Human | His | 32-224 aa | |
| HLA-DPA1-4840H | Recombinant Human HLA-DPA1 Protein, GST-tagged | Wheat Germ | Human | GST | 1-260 a.a. |
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| HLA-DPA1-5442Z | Recombinant Zebrafish HLA-DPA1 | Mammalian Cell | Zebrafish | His |
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| HLA-DPA1-5506HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
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| HLA-DPA1-3582HF | Recombinant Full Length Human HLA-DPA1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 260 amino acids |
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| HLA-DPA1-5290H | Recombinant Human HLA-DPA1 protein, His-tagged | E.coli | Human | His | 29-222aa |
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| RFL26724HF | Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dp Alpha 1 Chain(Hla-Dpa1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (29-260) |
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Involved Pathway
HLA-DPA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DPA1 participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asthma | IL10,TNF,HLA-DMA,HLA-DRB1,HLA-DQA2,IL4,HLA-DQB1,IL5,FCER1A,HLA-DRB5 |
| Graft-versus-host disease | HLA-E,IL1A,KLRD1,H2-AA,HLA-DMA,KLRC1,CD86,HLA-C,FASLG,HLA-DOB |
| Type I diabetes mellitus | H2-Q10,INS1,GAD1,LTA,Il2,IL12A,IL12B,FASLG,HLA-DQA1,ICA1 |
| ne network for IgA production | Il2,HLA-DRB5,CCL27B,HLA-DPB1,AICDA,CD86,MHC2A,CD28,IL15RA,CD80 |
| Rheumatoid arthritis | CCL20,IL1A,ATP6V0E2,IL1B,LTB,CXCL5,IFNG,H2-AA,VEGFA,H2-AB1 |
| Autoi | HLA-A,FASLG,IFNA13,IFNA4,HLA-DRA,Ifna11,TSHB,HLA-DQA1,HLA-DOA,IFNA14 |
| ne thyroid disease | CD28,TPO,H2-AB1,H2-Q10,HLA-B,HLA-G,CD40LG,IFNA10,HLA-C,IFNA4 |
| Tuberculosis | CLEC4M,IL10RB,HLA-DOB,RAB7,BAD,RAB5C,NFYB,HLA-DMB,HLA-DRA,IL12B |
| Staphylococcus aureus infection | HLA-DRB4,DSG1C,HLA-DRB5,CFH,ITGB2L,HLA-DMA,C5AR1,FPR2,HLA-DOA,FCGR2A |
Protein Function
HLA-DPA1 has several biochemical functions, for example, MHC class II receptor activity,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DPA1 itself. We selected most functions HLA-DPA1 had, and list some proteins which have the same functions with HLA-DPA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II receptor activity | HLA-DRA,HLA-DRB4,HLA-DQA2,HLA-DOA,HLA-DQA1,HLA-DQB1,HLA-DOB,HLA-DQB2,KRT17,HLA-DRB3 |
| peptide antigen binding | TAPBP,MHC1UBA,MHC1UXA2,HLA-C,MAML1,HLA-DQB1,HLA-DRA,HLA-DRB4,MHC1UDA,HLA-F |
Interacting Protein
HLA-DPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DPA1.
CD74;prfC;q7ard3_yerpe;iucD;q7chc4_yerpe
Resources
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References
- Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).
- Ollila, HM; Ravel, JM; et al. HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy. AMERICAN JOURNAL OF HUMAN GENETICS 96:136-146(2015).
