HLA-DOB

  • Official Full Name

    major histocompatibility complex, class II, DO beta

  • Overview

    HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

  • Synonyms

    HLA-DOB;major histocompatibility complex, class II, DO beta;HLA class II histocompatibility antigen, DO beta chain;DO beta chain;DOB;DOB_HUMAN;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DO beta chain;Major histocompatibility complex class II DO beta;Major histocompatibility complex class II DO beta chain;MHC class II antigen DOB
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DOB-13815H Recombinant Human HLA-DOB, GST-tagged E.coli Human GST 1-99a.a.
HLA-DOB-190H Recombinant Human HLA-DOB, His-tagged E.coli Human His 27-224aa
HLA-DOB-4839H Recombinant Human HLA-DOB Protein, GST-tagged Wheat Germ Human GST 27-116 a.a.
HLA-DOB-5504HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-DOB-6413H Recombinant Human HLA-DOB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    HLA-DOB involved in several pathways and played different roles in them. We selected most pathways HLA-DOB participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toxoplasmosis Casp3,ALOX5,LDLR,GNAI3,TGFB2,IKBKB,MAP3K7,BIRC2,LAMB3,LAMA1
    Antigen processing and presentation Ctsl,KIR3DL1,HSPA8,CD4,KIR3DL2,HSPA2,RFXAP,B2M,CTSS,HSP90AA1
    Intestinal i CXCL12,CD28,HLA-DQA2,IL6,CCL25B,HLA-DQB1,IL5,HLA-DPB1,ICOS,MHC2A
    Systemic lupus erythematosus HIST2H4,FCGR3A,H2AFV,GM14476,C8A,FCGR2A,HIST1H3C,CD86,HIST2H3A,H2AFY2
    Herpes simplex infection SRSF7B,HLA-DPB1,BLA,NFKBIAB,C1QBP,PVRL1B,IFNA2,IFNB,STAT1A,IKBKG
    ne thyroid disease IFNA10,TG,IFNA5,GZMB,CD40,IFNA4,HLA-DMA,HLA-DMB,HLA-G,IL5
    Viral myocarditis FYN,HLA-F,HLA-DQB1,H2-Q10,CD28,HLA-DRA,ITGB2L,MYH7,HLA-DRB5,ACTB
    Graft-versus-host disease H2-AB1,HLA-DRA,CD28,TNF,FAS,KIR3DL2,KLRD1,KIR3DL1,HLA-DPB1,GZMB
    Rheumatoid arthritis ATP6V1B2,ATP6V1A,ATP6V0E,ACP5,ATP6V1G2,IL23,IFNG,CCL3L1,TNFRSF11A,TNFSF11

    Protein Function

    HLA-DOB has several biochemical functions, for example, MHC class II protein complex binding,MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOB itself. We selected most functions HLA-DOB had, and list some proteins which have the same functions with HLA-DOB. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding YWHAE,ANXA11,HLA-DRB1,HSP90AB1,CD81,HLA-DMB,PKM,HLA-DOA,HLA-DMA,CD74
    MHC class II receptor activity HLA-DQA1,HLA-DQB2,HLA-DQA2,HLA-DOA,HLA-DRB4,HLA-DRA,HLA-DRB1,HLA-DQB1,HLA-DPA1,HLA-DRB3

    Interacting Protein

    HLA-DOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOB.

    Resources

    References

    • Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
    • van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).

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