HLA-DMB

  • Official Full Name

    major histocompatibility complex, class II, DM beta

  • Overview

    HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

  • Synonyms

    HLA-DMB;major histocompatibility complex, class II, DM beta;HLA class II histocompatibility antigen, DM beta chain;D6S221E;RING7;Class II histocompatibility antigen M beta chain;DMB;HLA class II histocompatibility antigen DM beta chain;Major histocompatibility complex class II DM beta;MHC class II antigen DMB;MHC class II antigen HLA DM beta chain;MHC class II HLA DMB;RING 7;OTTHUMP00000029257;OTTHUMP00000178732;MHC class II HLA-DMB;really interesting new gene 7 protein;MHC class II antigen HLA-DM beta chain;class II histocompatibility antigen, M
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-DMB-13813H Recombinant Human HLA-DMB, GST-tagged E.coli Human GST 1-263a.a.
HLA-DMB-324H Recombinant Human HLA-DMB Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
HLA-DMB-4837H Recombinant Human HLA-DMB Protein, GST-tagged Wheat Germ Human GST 22-129 a.a.
HLA-DMB-5500HCL Recombinant Human HLA 293 Cell Lysate HEK293 Human Non
HLA-DMB-3989H Recombinant Human HLA-DMB protein, His-tagged E.coli Human His 19-218aa
HLA-DMB-6533H Recombinant Human HLA-DMB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    HLA-DMB involved in several pathways and played different roles in them. We selected most pathways HLA-DMB participated on our site, such as Phagosome,Cell adhesion molecules (CAMs),Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome SFTPA1,ITGB3B,ATP6V1A,FCGR3,HLA-DRB1,C3A.3,TUBA3D,H2-AB1,HLA-B,ATP6V1E2
    Autoi CD40LG,HLA-DRB5,IFNA5,HLA-DOB,Ifna15,HLA-E,HLA-DPA1,Ifna11,HLA-C,FAS
    HTLV-I infection SLC25A4,FZD1,RAN,TP53,PRKACB,PDGFA,CD3G,TNFRSF13C,PPP3R1,POLB
    Influenza A PABPN1L,IFNGR1,AKT1,NLRX1,TLR3,TNFRSF10B,KPNA2,TLR4,HLA-DRB4,PIK3R2
    Type I diabetes mellitus Il2,HLA-F,Fasl,HLA-E,HLA-DRB4,CD86,FAS,GAD1,INS2,H2-AB1
    Systemic lupus erythematosus HIST1H4H,HLA-DQA1,H2AFB3,TRIM21,HIST2H4,H2AFY,GM14482,HIST1H2AE,HIST1H4C,HLA-DPA1
    Toxoplasmosis IFNGR1,PPIF,MYD88,LAMB4,STAT3,HLA-DOB,TLR2,NFKBIB,TNF,LAMA4
    Allograft rejection Il2,HLA-DPA1,GZMB,HLA-DRB1,H2-AA,HLA-DOB,HLA-DQB1,H2-Q10,Fasl,TNF
    Cell adhesion molecules (CAMs) ITGB1B.2,CD276,CLDNE,CDH15,Icosl,CLDN15,CD274,PVRL1B,ITGB8,CD2

    Protein Function

    HLA-DMB has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMB itself. We selected most functions HLA-DMB had, and list some proteins which have the same functions with HLA-DMB. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding HLA-DRA,HSPA8,HLA-DOA,HSP90AB1,PKM,YWHAE,HSP90AA1,CD81,CD74,HLA-DMA

    Interacting Protein

    HLA-DMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMB here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMB.

    HLA-DMA;HLA-DRB1;TEAD1;MDM2

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