HLA-C
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Official Full Name
HLA-C major histocompatibility complex, class I, C [ Homo sapiens ] -
Overview
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described -
Synonyms
major histocompatibility complex, class I, C;4933;Ensembl:ENSG00000204525;FLJ27082;HLA class I histocompatibility antigen, Cw-1 alpha chain;MHC class I antigen heavy chain HLA-C;human leukocyte antigen-C alpha chain;major histocompatibility antigen HLA-C;HLA class I histocompatibility antigen, C alpha chain;HLC-C;D6S204;PSORS1;HLA-JY3
Recombinant Proteins
- Human
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-C-13811H | Recombinant Human HLA-C, GST-tagged | E.coli | Human | GST | 28-306a.a. | |
| HLA-C-268H | Recombinant Human major histocompatibility complex, class I, C, His-tagged | E.coli | Human | His | 25-308 a.a. |
|
| HLA-C-4834H | Recombinant Human HLA-C Protein, GST-tagged | Wheat Germ | Human | GST | 1-336 a.a. |
|
| HLA-C-5498HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | Human | Non |
|
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| HLA-C-242H | Recombinant Human HLA-C Protein, His-tagged | E.coli | Human | His | Ser48~Thr305 |
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| HLA-C-269H | Recombinant Human HLA-C protein, His-tagged | HEK293 | Human | His |
|
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| HLA-C-2940H | Recombinant Human HLA-C Protein (Ser48-Thr305), His tagged | E.coli | Human | His | Ser48-Thr305 |
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| HLA-C-3560HF | Recombinant Full Length Human HLA-C Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 336 amino acids |
|
Involved Pathway
HLA-C involved in several pathways and played different roles in them. We selected most pathways HLA-C participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | PIK3R1,HSPB1,AKT2,POLR2J2,POLR2E,HLA-DQA2,CCNA1,RIPK1,MAP2K6,IKBKG |
| Allograft rejection | GZMB,H2-AA,TNF,Il2,HLA-DOB,HLA-DRB1,CD40LG,HLA-F,HLA-A,HLA-DRB4 |
| Endocytosis | FGFR4,PSD2,RAB5AB,VPS26B,WASL,RHOAA,EHD3,SH3GL3A,SMAP2,SNX4 |
| Type I diabetes mellitus | FAS,FASLG,H2-AB1,CD86,HLA-DMA,HLA-DRB1,HLA-DQA1,GAD1,GZMB,PTPRN2 |
| Herpes simplex infection | EEF1DB,TRAF5,EIF2AK1,Fasl,CUL1B,MHC2DEB,HCFC2,GTF2IRD1,TAF10,HMGN1 |
| HTLV-I infection | HLA-DMA,GM-CSF,POLD2,IL15RA,CD3G,RAN,HLA-A,WNT10B,TERT,HLA-DPB1 |
| Antigen processing and presentation | KLRC4,IFI30,HLA-DRB5,HSPA1B,HLA-A,KIR2DL1,HSPA5,KIR3DL1,HLA-DOA,HLA-DQB1 |
| Viral carcinogenesis | HIST1H2BB,CREB3L2,HIST1H4H,ACTN1,PIK3R5,MAD1L1,GTF2H2C,STAT5B,STAT5A,HIST1H2BN |
| Viral myocarditis | HLA-F,HLA-DQA1,ABL1,EIF4G3,CASP8,ICAM1,HLA-DQB1,LAMA2,CD28,ITGB2 |
Protein Function
HLA-C has several biochemical functions, for example, TAP binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-C itself. We selected most functions HLA-C had, and list some proteins which have the same functions with HLA-C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP binding | HLA-B,H2-Q10,HLA-A |
| peptide antigen binding | H2-AB1,TAP1,MHC1ZHA,HLA-DRB3,MHC1UXA2,MHC1UJA,HLA-F,HLA-DQB1,TUBB3,CD209 |
Interacting Protein
HLA-C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-C here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-C.
Resources
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References
- Law, MG; Achhra, A; et al. Clinical and demographic factors associated with low viral load in early untreated HIV infection in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial. HIV MEDICINE 16:37-45(2015).
- Mahil, SK; Capon, F; et al. Genetics of Psoriasis. DERMATOLOGIC CLINICS 33:1-+(2015).
