HKDC1
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Official Full Name
hexokinase domain containing 1 -
Synonyms
HKDC1;hexokinase domain containing 1;FLJ22761;FLJ37767;Q2TB90;MGC125688;OTTHUMP00000019718;putative hexokinase HKDC1;Hexokinase domain-containing protein 1;EC 2.7.1;EC 2.7.1.1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- HEK293
- Wheat Germ
- Mammalian Cells
- DDK
- Myc
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HKDC1-315H | Recombinant Human HKDC1 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| HKDC1-4828H | Recombinant Human HKDC1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HKDC1-6544Z | Recombinant Zebrafish HKDC1 | Mammalian Cells | Zebrafish | His |
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| HKDC1-7715M | Recombinant Mouse HKDC1 Protein | Mammalian Cells | Mouse | His |
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| HKDC1-795HCL | Recombinant Human HKDC1 cell lysate | Human | Non |
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| HKDC1-1345H | Recombinant Human HKDC1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Hkdc1-3408M | Recombinant Mouse Hkdc1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| HKDC1-4230M | Recombinant Mouse HKDC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HKDC1-4230M-B | Recombinant Mouse HKDC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HKDC1 involved in several pathways and played different roles in them. We selected most pathways HKDC1 participated on our site, such as Glycolysis / Gluconeogenesis,Fructose and mannose metabolism,Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HKDC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Starch and sucrose metabolism | AMY2A2,HK1,AGLA,G6PCA.2,Amy1,PYGM,G6PC,UGT1A2,UGT1A7C,GBE1 |
| Fructose and mannose metabolism | HK2,GMPPAB,ALDOB,FPGT,GMPPB,GMDS,PFKL,TPI1B,AKR1B7,PFKM |
| Amino sugar and nucleotide sugar metabolism | HEXA,CYB5RL,GPIA,GPI1,NANP,FPGT,GALT,nanA,GMPPAA,GNPDA1 |
| HIF- signaling pathway | MTOR,NPPA,RPS6KB1,HIF1A,ARNT,TLR4,Il6ra,EPO,PGK1,TEK |
| Galactose metabolism | UGP2B,HK1,B4GALT1,LALBA,G6PC,GAA,GALM,B4GALT2,G6PCA.2,SI |
| Insulin signaling pathway | G6PC,PRKAR2A,MAP2K1,BAD,MAPK9,SHC4,PKLR,ARAF,MKNK2,PHKG1A |
| Butirosin and neomycin biosynthesis | HK1,HK3,HK2 |
| Type II diabetes mellitus | INS-IGF2,SOCS3,PIK3R3,TNF,CACNA1G,SOCS4,PRKCZ,PDX1,PIK3R2,PIK3R5 |
| Central carbon metabolism in cancer | HK3,GLS,SLC16A3,PFKL,ERBB2,SIRT3,IDH1,HRAS,PKM2,SLC7A5 |
Protein Function
HKDC1 has several biochemical functions, for example, ATP binding,fructokinase activity,glucokinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HKDC1 itself. We selected most functions HKDC1 had, and list some proteins which have the same functions with HKDC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fructokinase activity | HK3,HK1,HK2 |
| mannokinase activity | HK3,HK2,HK1 |
| ATP binding | MMAB,PSMC4,KDR,ERBB2,KIF1C,LACE1B,DDX20,Abca2,PPP1CA,AGAP2 |
| glucokinase activity | HK3,HK1,HK2 |
| glucose binding | SLC2A3,G6PD,G6PDX,HK2,SLC2A8,UGP2,HK3,PYGL,HK1,GYS1 |
Interacting Protein
HKDC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HKDC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HKDC1.
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References
- Hu, CJ; Song, G; et al. Identification of New Autoantigens for Primary Biliary Cirrhosis Using Human Proteome Microarrays. MOLECULAR & CELLULAR PROTEOMICS 11:669-680(2012).
- Hashimoto, M; Wilson, JE; et al. Kinetic and regulatory properties of HKI+, a modified form of the type I isozyme of mammalian hexokinase in which interactions between the N- and C-terminal halves have been disrupted. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 399:109-115(2002).
