HEY2
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Official Full Name
hes-related family bHLH transcription factor with YRPW motif 2 -
Overview
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
HEY2;hes-related family bHLH transcription factor with YRPW motif 2;GRL;CHF1;HRT2;HERP1;HESR2;bHLHb32;GRIDLOCK;hairy/enhancer-of-split related with YRPW motif protein 2;HRT-2;hCHF1;hHRT2;HESR-2;protein gridlock homolog;HES-related repressor protein 1;HES-related repressor protein 2;hairy-related transcription factor 2;cardiovascular helix-loop-helix factor 1;class B basic helix-loop-helix protein 32;hairy and enhancer of split-related protein 2;cardiovascular basic helix-loop-helix factor 1;hairy/enhancer-of-split related with YRPW motif 2
Recombinant Proteins
- Rhesus macaque
- Human
- Zebrafish
- Mouse
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HEY2-2073R | Recombinant Rhesus monkey HEY2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| HEY2-279H | Recombinant Human HEY2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| HEY2-4717H | Recombinant Human HEY2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HEY2-9160Z | Recombinant Zebrafish HEY2 | Mammalian Cells | Zebrafish | His |
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| HEY2-5574HCL | Recombinant Human HEY2 293 Cell Lysate | HEK293 | Human | Non |
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| Hey2-1119M | Recombinant Mouse Hey2 Protein, MYC/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| HEY2-1894R | Recombinant Rhesus Macaque HEY2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HEY2-1894R-B | Recombinant Rhesus Macaque HEY2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HEY2-3529HF | Recombinant Full Length Human HEY2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 337 amino acids |
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| HEY2-5992H | Recombinant Human HEY2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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Involved Pathway
HEY2 involved in several pathways and played different roles in them. We selected most pathways HEY2 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,Constitutive Signaling by NOTCH1 PEST Domain Mutants,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Disease | OGN,KPNA3,APOBEC3G,CHMP4B,NMT2,CCR5,JAG1,CUX1,PPIA,gag |
| Neural Crest Differentiation | DLX5,DCT,OLIG3,CDH7,MIA,TFAP2B,LHX1,GBX2,CTBP2,ZIC1 |
| Heart Development | NKX2-5,GATA6,TBX20,IRX4,BMP10,TBX5,SMYD1,NKX2,HEY1,FOXC2 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | HDAC6,HDAC5,HEY1,JAG2,HEYL,CCNC,JAG1,MIB1,ADAM10,CDK8 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | CCNC,HEY1,JAG1,HEYL,ADAM10,HDAC5,JAG2,HDAC6,MIB1,CDK8 |
| Diseases of signal transduction | CTBP1,JAG1,OPN1SW,CPSF6,KREMEN2,LRRFIP1,TNKS2,KREMEN1,RBP4,HEYL |
| Delta-Notch Signaling Pathway | JAG1,HIVEP3,YY1,HES6,NOV,ADAM10A,SMAD3B,CNTFR,TUBB3,CNTN1B |
| NOTCH1 Intracellular Domain Regulates Transcription | TLE1,HEY1,TLE2,TLE3,TUBB3,HEYL,TLE4 |
Protein Function
HEY2 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding,histone deacetylase binding,microsatellite binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HEY2 itself. We selected most functions HEY2 had, and list some proteins which have the same functions with HEY2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | Trl,EN2,SMAD3,HOXC5,PRRX1A,PAX6A,GSX2,CREB3L3A,GATA1,HOXA3 |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | PAX7,MEF2C,HEYL,SMAD3,MAX,NKX3,TFAP2B,HEY1 |
| RNA polymerase II activating transcription factor binding | BEX1,CREBBP,NFE2L2,LMO2,TBX6,JUN,IFI27,EGR2,HIPK2,LDB1 |
| microsatellite binding | HEY1,HEYL |
| transcription factor activity, sequence-specific DNA binding | ZSCAN16,ZNF45,HMGA1A,LHX8A,TAF13,SLC12A9,EOMESB,ZNF621,DMRTC2,RFX1A |
| histone deacetylase binding | MAGEA2B,NCOR2,CEBPA,NKX3-1,BCOR,MECP2,ZNHIT1,SIX3,D7ERTD443E,PRDM1 |
| protein dimerization activity | ATOH1,NUP210,HELT,EBF2,GARS,HNF1BA,HIF1AL,SIM1,PRDX5,BHLHE41 |
| transcription factor activity, protein binding | HEYL,HEY1 |
| protein binding | FIS1,CCBL1,CACNB2,MOB3C,NIF3L1,SOCS2,ROPN1L,MED1,GFM1,MARCKSL1 |
Interacting Protein
HEY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEY2.
TRAF1;RBPMS;SIRT1;HTT;PLSCR1;ENO1;ATXN1
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References
- Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
- Brandt, WD; Schreck, KC; et al. Notch Signaling Activation in Pediatric Low-Grade Astrocytoma. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:121-131(2015).
