HERC5
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Official Full Name
hect domain and RLD 5 -
Overview
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. -
Synonyms
HERC5;hect domain and RLD 5;E3 ISG15--protein ligase HERC5;CEB1;CEBP1;HECT domain and RCC1 like domain containing protein 5;Herc6;Cyclin E binding protein 1;Cyclin-E-binding protein 1;HECT domain and RCC1-like domain-containing protein 5;HECT E3 ubiquitin ligase;HERC5_HUMAN;cyclin-E binding protein 1;probable E3 ubiquitin-protein ligase HERC5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HERC5-178H | Recombinant Human HERC5, His-tagged | E.coli | Human | His | 681-1024aa |
|
| HERC5-4693H | Recombinant Human HERC5 Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
HERC5 involved in several pathways and played different roles in them. We selected most pathways HERC5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes,Cytokine Signaling in Immune system,ISG15 antiviral mechanism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | RNF216,PCBP2,TAX1BP1,TANK,RNF135,TAX1BP1B,NLRC5 |
| Immune System | ICAM4,DEFB121,IL1RN,PELI1,TXNIPA,IFI6,FCN1,SIGLEC15,ASB2,CD300LF |
| Innate Immune System | C1rb,NLRP4,BTR30,TXNIPA,DEFB103A,NLRP4E,POLR3H,DEFA1,CD300E,TXNIP |
| Negative regulators of RIG-I/MDA5 signaling | CYLD,PCBP2,TAX1BP1,RNF135,RNF216,TAX1BP1B,NLRC5 |
| Interferon Signaling | MX2,IRF9,IFI30,TRIM45,TRIM2,XAF1,TRIM10,IRF4,ISG20,IFIT12 |
| Cytokine Signaling in Immune system | TRIM48,LAMTOR2,UBE2L6,ADAR,TNFRSF13C,EIF4E3,CSF2RA,SPRED2,JAK1,FGF8B |
| ISG15 antiviral mechanism | EIF4E3,KPNA3,EIF4G2A,KPNA5,IFIT12,MX2,IFIT10,ARIH1,EIF4G2,UBE2L6 |
| Antiviral mechanism by IFN-stimulated genes | ARIH1,EIF4G1,EIF4G2,IFIT12,EIF4G2A,EIF4A2,NUP35,EIF4E3,EIF4EB,NUP50 |
Protein Function
HERC5 has several biochemical functions, for example, ISG15 transferase activity,ligase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC5 itself. We selected most functions HERC5 had, and list some proteins which have the same functions with HERC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity | BRAP,RNF25,UBR1,RNF144AA,TRIM3,DZIP3,RLIM,UBE2W,PRPF19,MED24 |
| ISG15 transferase activity | UBE2L6,UBE2E1,UBE2E2 |
| ligase activity | RNF34,HECTD3,SH3RF2,EGR2,RNF31,MKRN1,NEDD4,NAPRT,MSL2,RNF187 |
| protein binding | MMRN2,EIF1AX,RAB9A,XAGE3,EPHB4,MYOZ1,ATF7,KCNA4,SARM1,RNH1 |
| poly(A) RNA binding | MRPS12,DNAJC2,IPO5,PRKDC,NSUN5,RBM4,POLR2A,SRPR,PELP1,MAK16 |
Interacting Protein
HERC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC5.
NUDCD2;UBE2E1;UBE2E3;UBE2E2;Srp72;RPL10;TTK;SNCA;HNRNPU;Mta1;GSG2;Rrbp1;Nrip3;AGO2
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References
- Huang, YF; Bulavin, DV; et al. Oncogene-mediated regulation of p53 ISGylation and functions. ONCOTARGET 5:5808-5818(2014).
- Raterman, HG; Vosslamber, S; et al. The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients. ARTHRITIS RESEARCH & THERAPY 14:-(2012).
- Malhotra, S; Bustamante, MF; et al. Search for Specific Biomarkers of IFN beta Bioactivity in Patients with Multiple Sclerosis. PLOS ONE 6:-(2011).
