HEBP1
-
Official Full Name
heme binding protein 1 -
Overview
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. -
Synonyms
HEBP1;heme binding protein 1;heme-binding protein 1;HBP;HEBP;p22HBP
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect Cells
- In Vitro Cell Free System
- GST
- His
- Non
- DDK&Myc
- Fc
- Avi&Fc&His
Involved Pathway
HEBP1 involved in several pathways and played different roles in them. We selected most pathways HEBP1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),Formyl peptide receptors bind formyl peptides and many other ligands,G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Formyl peptide receptors bind formyl peptides and many other ligands | FPR-RS4,FPR-RS6,ANXA1,FPR-RS3 |
| Peptide ligand-binding receptors | CCL35.2,GPR77,RXFP2,TAC3,EDNRAB,NMBB,QRFP,NMB,PENKA,PNOCB |
| Signal Transduction | RLN3,OMG,LEO1,PRLH,RGS12,EMR4,DHRS3A,DEPDC7,MYO9B,CRHB |
| GPCR ligand binding | TAAR1,ADRA2B,GRP,ADCYAP1R1,RAMP2,RGR,UTS2,LPAR2B,PRLH,PROKR2 |
| G alpha (i) signalling events | DRD2,RHOL,PNOC,LPAR2B,CCL19A.2,OXGR1A.1,GAL,APLNR,LPAR2A,RGS18 |
| Class A/1 (Rhodopsin-like receptors) | INSL3,OPN1SW1,TAAR1,GPR65,DRD3,FPR-RS6,CCR5,PNOC,QRFPR,SSTR2 |
| Signaling by GPCR | CNR2,PROK1,OXGR1A.3,RGS11,OXGR1A.1,OBSCN,OR10A5,NMB,OR56A1,GPBAR1 |
| GPCR downstream signaling | PENK,GPBAR1,OPN1MW,LPAR1,PTHLHA,CHRM2,ABHD12,GAL,OXTRL,S1PR1 |
Protein Function
HEBP1 has several biochemical functions, for example, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HEBP1 itself. We selected most functions HEBP1 had, and list some proteins which have the same functions with HEBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | CYP2A4,HBA-X,HBAA1,CYP2AA9,HBQ1,CYP2X8,HBAA,CYP2D26,CYP2C54,HBA2 |
Interacting Protein
HEBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEBP1.
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References
- Cagliani, R; Pozzoli, U; et al. Crohn's Disease Loci Are Common Targets of Protozoa-Driven Selection. MOLECULAR BIOLOGY AND EVOLUTION 30:1077-1087(2013).
- Nakasone, K; Nagahama, Y; et al. hebp3, a Novel Member of the Heme-Binding Protein Gene Family, Is Expressed in the Medaka Meninges With Higher Abundance in Females Due to a Direct Stimulating Action of Ovarian Estrogens. ENDOCRINOLOGY 154:920-930(2013).
