HDC
-
Official Full Name
histidine decarboxylase -
Overview
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone. -
Synonyms
HDC;histidine decarboxylase;MGC163399
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Yeast
- In Vitro Cell Free System
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
HDC involved in several pathways and played different roles in them. We selected most pathways HDC participated on our site, such as Histidine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | AGPAT4,EXT1C,CYP1A,GALNT18A,POLA1,DPYD,GSS,MBOAT2B,GMPPAB,ASMT |
| Histidine metabolism | AOC1,ALDH3B1,AMDHD1,ALDH1A3,MAOB,CNDP2,ALDH9A1,ALDH9A1A.1,CNDP1,ABP1 |
Protein Function
HDC has several biochemical functions, for example, histidine decarboxylase activity,protein binding,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDC itself. We selected most functions HDC had, and list some proteins which have the same functions with HDC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | SHMT1,SPTLC2A,AGXT2L2,CTHL,GOT2B,PDXDC2P,Alb,GAD1B,ABAT,MOSC2 |
| protein binding | BCL10,TLE3,SIAH1,NUP85,TBX5A,BAG6,LDOC1,UIMC1,C19orf44,LANCL2 |
Interacting Protein
HDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDC here. Most of them are supplied by our site. Hope this information will be useful for your research of HDC.
DTX2;DTX2
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References
- Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).
- Schneider, EH; Neumann, D; et al. Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 47:101-121(2014).
