HAND1

  • Official Full Name

    heart and neural crest derivatives expressed 1

  • Overview

    The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]

  • Synonyms

    HAND1;heart and neural crest derivatives expressed 1;Hxt;eHand;Thing1;bHLHa27;heart- and neural crest derivatives-expressed protein 1;class A basic helix-loop-helix protein 27;extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • His&T7
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
HAND1-13662H Recombinant Human HAND1, GST-tagged E.coli Human GST 1-215a.a.
HAND1-2786R Recombinant Rat HAND1 Protein Mammalian Cell Rat His
HAND1-4566H Recombinant Human HAND1 Protein, GST-tagged Wheat Germ Human GST
HAND1-6524C Recombinant Chicken HAND1 Mammalian Cell Chicken His
HAND1-7171H Recombinant Human Heart And Neural Crest Derivatives Expressed 1, His-tagged E.coli Human His 1-215aa
Hand1-7851M Recombinant Mouse Hand1 protein, His & T7-tagged E.coli Mouse His&T7 Met1~Gln216
HAND1-5639HCL Recombinant Human HAND1 293 Cell Lysate HEK293 Human Non
HAND1-2440R Recombinant Rat HAND1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
HAND1-2440R-B Recombinant Rat HAND1 Protein Pre-coupled Magnetic Beads HEK293 Rat
HAND1-3349HF Recombinant Full Length Human HAND1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 215 amino acids
HAND1-7172H Recombinant Human HAND1 protein, His-T7-tagged E.coli Human His&T7 Met1~Gln215

    Involved Pathway

    HAND1 involved in several pathways and played different roles in them. We selected most pathways HAND1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAND1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells BMPR1A,WNT5B,KRAS,SMAD4,INHBB,ESRRB,BMP2,Fzd4,ACVR1B,FGFR1

    Protein Function

    HAND1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,bHLH transcription factor binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAND1 itself. We selected most functions HAND1 had, and list some proteins which have the same functions with HAND1. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding PAX2,RNF19A,TNFRSF10A,IFI203,KEAP1B,TRIB2,JUND,HMGA1,GPX3,TAF7L
    transcription coactivator activity BRD7,CTNNB1,RFXAP,GABPA,PIAS1,TUBB3,TRIM32,MED26,USP16,BRCA1
    protein binding MSH2,BLOC1S3,TMEM123,PTGES3,GKAP1,CCDC28B,COL6A5,WNT2,ZNF581,BTN3A1
    contributes_to transcription regulatory region DNA binding TAF1,TCF12,HDAC4,HDAC5,ATF4,NFYC,NFYB,NFYA,RXRA,NR1H3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding PRDM5,HINFP,RFX8,PITX2,MEF2A,ZNF460,KLF16,BCL11A,ZFP639,FOXJ2
    identical protein binding PYCARD,PTK6,RASSF3,ROBO2,PDCD6,SAFB2,IFI203,CDC42BPA,HOOK1,HSD17B10
    bHLH transcription factor binding TCF3A,SMAD3,IKZF4,TCF12,TCF4,PSMD9,SIRT1,EP300,ASCL1,ISL1
    enzyme binding TSPAN5,PPP1R3B,NFKBIA,PIAS3,SIRT1,GSTM2,TGFB1,DNMT3L,APP,HDAC3
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding MLXIPL,NFIL3-2,BATF3,TGIF1,POU4F2,OVOL1,SALL1,PROX2,PRDM1,ETS2

    Interacting Protein

    HAND1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAND1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAND1.

    Resources

    Research Area

    Early Mesodermal Lineage Markers
    Ectodermal Lineage Markers
    Mesodermal Lineage Markers

    References

    • Org, T; Duan, D; et al. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO JOURNAL 34:759-777(2015).
    • Li, D; Ji, L; et al. Characterization of Circulating MicroRNA Expression in Patients with a Ventricular Septal Defect. PLOS ONE 9:-(2014).

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