GYS2
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Official Full Name
glycogen synthase 2 (liver) -
Overview
The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. -
Synonyms
GYS2;glycogen synthase 2 (liver);glycogen [starch] synthase, liver;Glycogen starch synthase liver;EC 2.4.1.11;Glycogen synthase 2 liver
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
GYS2 involved in several pathways and played different roles in them. We selected most pathways GYS2 participated on our site, such as Starch and sucrose metabolism,PIK-Akt signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PYGMA,PTENB,FOXO1B,INSRA,PYGL,PPARA,AKT1,MLXIPL,PTPN11A,PRKCB |
| AMPK signaling pathway | CAB39,PDPK1,RHEB,CAB39L,SCD,SREBF1,STK11,CCNA1,EEF2K,PPP2R2C |
| Insulin signaling pathway | INS1,FBP1A,PPP1CB,INSB,MAP2K2A,SOCS1,MTOR,PPP1R3D,PDPK1B,TSC1A |
| Starch and sucrose metabolism | UGT2A3,UGP2,GBA3,UGT1A3,UGT2B15,G6PCA.2,GAA,AMY2A3,AMY2A2,SI |
| PIK-Akt signaling pathway | FGF12,EIF4E1B,MAPK3,IFNA7,ITGA2,IFNAR1,PDGFRA,ITGB6,PPP2R5E,VEGFA |
Protein Function
GYS2 has several biochemical functions, for example, glycogen (starch) synthase activity,glycogen synthase activity, transferring glucose-1-phosphate,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GYS2 itself. We selected most functions GYS2 had, and list some proteins which have the same functions with GYS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycogen synthase activity, transferring glucose-1-phosphate | GYS1 |
| glycogen (starch) synthase activity | GYS1 |
| protein homodimerization activity | ERN1,TCF4,GLIPR2,NR6A1A,PVRL1B,TPD52L2,NLRC4,FAM109B,ABCB10,DROSHA |
Interacting Protein
GYS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GYS2.
GYG2;TNFRSF1A;GABARAP
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References
- Lau, MY; Han, H; et al. Association of cyclin D and estrogen receptor alpha 36 with hepatocellular adenomas of female mice under chronic endoplasmic reticulum stress. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 28:576-583(2013).
- Vadrot, N; Ghanem, S; et al. Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3 beta and p53 in Response to Tumor Necrosis Factor alpha. PLOS ONE 7:-(2012).
