GYPA
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Official Full Name
glycophorin A (MNS blood group) -
Overview
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPA gene consists of 7 exons and has 97% sequence homology with GYPB from the 5 UTR to the coding sequence encoding the first 45 amino acids. GYPB accounts for S, s and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are resulted from gene recombinations between GYPA and GYPB. These antigens are expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells (mature erythrocytes are characteristically CD235a positive and CD45 and CD71 negative). -
Synonyms
Glycophorin A + B;GYPA;glycophorin A (MNS blood group);glycophorin A (includes MN blood group) , glycophorin A (MN blood group) , MNS;glycophorin-A;CD235a;GPA;MN;glycophorin MiI;glycophorin MiV;glycophorin SAT;glycophorin Erik;glycophorin A, GPA;MN sialoglycop
Recombinant Proteins
- Human
- Mouse
- Sus scrofa (Pig)
- Macaca fuscata fuscata (Japanese macaque)
- Dog
- Mus musculus
- HEK293
- E.coli
- Wheat Germ
- Human Cells
- Yeast
- In Vitro Cell Free System
- Mammalian Cells
- Fc
- His
- Non
- His&Flag&StrepII
- GST
- His&Fc
- His&Fc&Avi
Involved Pathway
GYPA involved in several pathways and played different roles in them. We selected most pathways GYPA participated on our site, such as Hematopoietic cell lineage,Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | HBA-A2,ITGAL,IL1B,HGF,VCAM1,CD36,IL-8,TGFB3,HBB,GYPB |
| Hematopoietic cell lineage | CSF1,Kitl,CD1C,CD8B1,CD8B,ITGA6,CD24,FCGR1,IL5,ITGA2B |
Protein Function
GYPA has several biochemical functions, for example, identical protein binding,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GYPA itself. We selected most functions GYPA had, and list some proteins which have the same functions with GYPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | KHDRBS1,GCG,ACY3,E2F7,NFKBIA,S100A1,TRAF2,GBP1,PITX2,GUCY2E |
| virus receptor activity | CXADR,SELPLG,SERPINB4,CLEC5A,ITGB6,CLEC4G,CLDN1,CD80,ITGB3,GPR172B |
Interacting Protein
GYPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYPA here. Most of them are supplied by our site. Hope this information will be useful for your research of GYPA.
Resources
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References
- Polin, H; Danzer, M; et al. MN typing discrepancies based on GYPA-B-A hybrid. VOX SANGUINIS 107:393-398(2014).
- Saetear, P; Perrin, AJ; et al. Quantification of Plasmodium-host protein interactions on intact, unmodified erythrocytes by back-scattering interferometry. MALARIA JOURNAL 14:-(2015).
