GUSB
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Official Full Name
glucuronidase, beta -
Overview
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. There are many pseudogenes of this locus in the human genome. -
Synonyms
GUSB;glucuronidase, beta;beta-glucuronidase;Ac2-223;asd;Beta G1;Beta glucuronidase;Beta-G1;BG;BGLR;BGLR_HUMAN;FLJ39445;Glucuronidase beta;Gur;Gus;Gus-r;Gus-s;Gus-t;Gus-u;Gut;MPS 7;MPS7;OTTHUMP00000159848;OTTHUMP00000210106;beta-D-glucuronidase
Recombinant Proteins
- Human
- Helix pomatia
- Rat
- Chicken
- Mouse
- Mammalian cells
- Helix Pomatia
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- Baculovirus cells
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- His&T7
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
GUSB involved in several pathways and played different roles in them. We selected most pathways GUSB participated on our site, such as Pentose and glucuronate interconversions,Starch and sucrose metabolism,Glycosaminoglycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUSB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GGT5,SYNJ2,OLAH,HEXA,BDH1,C1GALT1A,STT3A,ATP6V0B,HADHAB,PLA2G2D |
| Starch and sucrose metabolism | G6PC2,PYGL,GBA3,AMY2B,ENPP1,HK2,AMY1A,AMY2A5,Amy1,G6PC3 |
| Glycosaminoglycan degradation | ARSB,HEXB,GALNS,NAGLU,HGSNAT,HEXA,IDUA,HYAL6,HPSE,HPSE2 |
| Porphyrin and chlorophyll metabolism | COX15,UGT1A6A,UGT2A3,UGT2B15,UGT1A2,UGT1AB,EPRS,CP,UGT1A7C,BLVRA |
| Pentose and glucuronate interconversions | RPE,UGT1A6,DCXR,UGT2A1,UGP2,UGT1A6A,DHDHL,ALDH2.2,ALDH2.1,XYLB |
| Lysosome | SGSH,ATP6V0A2B,GALCA,ARSA,AP3D1,NAPSA,PSAP,ASAH1B,ATP6V0CB,PSAPL1 |
| Drug metabolism - other enzymes | UGT5G1,UGT1A7C,UPP2,TK1,UCKL1,UGT1AB,PNAT10,TPMT,NAT2,Ces2c |
Protein Function
GUSB has several biochemical functions, for example, beta-glucuronidase activity,protein domain specific binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GUSB itself. We selected most functions GUSB had, and list some proteins which have the same functions with GUSB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-glucuronidase activity | HPSE |
| protein domain specific binding | EHD2,VRK2,STX1B,HOMER2,HNRNPM,COX4I2,MED12,VAPA,DYNLL1,ARFIP2 |
| receptor binding | APOL2,AGXT,HSPA1B,PVRL2,REN,MAG,PPY,CCL2,WNT7AA,PTPRD |
Interacting Protein
GUSB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUSB here. Most of them are supplied by our site. Hope this information will be useful for your research of GUSB.
GIT2;A2M;cona_canen
Resources
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References
- Boado, RJ; Pardridge, WM; et al. Genetic engineering of IgG-glucuronidase fusion proteins. JOURNAL OF DRUG TARGETING 18:205-211(2010).
- Zhang, Y; Wang, Y; et al. Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer. PHARMACEUTICAL RESEARCH 25:400-406(2008).
