GSTT1
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Official Full Name
glutathione S-transferase theta 1 -
Overview
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. -
Synonyms
GSTT1;glutathione S-transferase theta 1;glutathione S-transferase theta-1;EC 2.5.1.18;Glutathione S transferase 5;Glutathione S transferase theta 1;Glutathione transferase T1 1;Glutathione transferase T1-1;GST 5 5;GST CL1;GST class theta 1;GST class-theta-1;GSTT1_HUMAN;OTTHUMP00000198547;OTTHUMP00000198549;EC 2.5.1.18;Glutathione S transferase 5;GST class-theta-1;GSTT1;Glutathione S Transferase theta 1;GST theta 1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GSTT1-13582H | Recombinant Human GSTT1, His-tagged | E.coli | Human | His | 1-240a.a. | |
| GSTT1-180H | Recombinant Human Glutathione S-transferase Theta 1, His-tagged | E.coli | Human | Non |
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| GSTT1-2476H | Recombinant Human Glutathione S-transferase Theta 1 | E.coli | Human | Non |
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| GSTT1-26091TH | Recombinant Human GSTT1, His-tagged | E.coli | Human | His | Full L. |
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| GSTT1-28121TH | Recombinant Human GSTT1, His-tagged | E.coli | Human | His | 240 amino acids |
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| GSTT1-4429H | Recombinant Human GSTT1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| Gstt1-617M | Recombinant Mouse Gstt1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Leu7~Gln240 |
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| Gstt1-618R | Recombinant Rat Gstt1 protein, His & T7-tagged | E.coli | Rat | His&T7 | Leu7~Leu231 |
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| GSTT1-6917C | Recombinant Chicken GSTT1 | Mammalian Cells | Chicken | His |
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| GSTT1-7341M | Recombinant Mouse GSTT1 Protein | Mammalian Cells | Mouse | His |
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| GSTT1-908H | Recombinant Human GSTT1 Protein, His-tagged | E.coli | Human | His |
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| GSTT1-312HCL | Recombinant Human GSTT1 lysate | HEK293 | Human | Non |
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| GSTT1-2223H | Recombinant Human GSTT1 Protein, His-tagged | E.coli | Human | His | Phe20-Gln229 |
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| GSTT1-3368HF | Recombinant Full Length Human GSTT1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 240 amino acids |
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| GSTT1-3981M | Recombinant Mouse GSTT1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GSTT1-3981M-B | Recombinant Mouse GSTT1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
GSTT1 involved in several pathways and played different roles in them. We selected most pathways GSTT1 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | SRM,GPX2,GPX6,GSTP1,GSTA4,LAP3,GSTA,GSTAL,GSTM2,GSTT1B |
| Metabolism of xenobiotics by cytochrome P | GSTT2B,ADH1,AKR7A5,UGT2B7,MGST1.1,ALDH3A1,UGT1A4,UGT1A6A,GSTM4,GSTM5 |
| Drug metabolism - cytochrome P | MGST2,GSTM7,MGST1.2,MAOB,GSTA3,MGST1,GSTM1,ALDH3B2,ALDH3A1,FMO2 |
| Chemical carcinogenesis | ADH5,CYP2C18,ADH1C,UGT1A2,GSTT2,UGT1A7C,CYP2C39,ADH6,GSTA3,Nat3 |
Protein Function
GSTT1 has several biochemical functions, for example, glutathione peroxidase activity,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTT1 itself. We selected most functions GSTT1 had, and list some proteins which have the same functions with GSTT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione peroxidase activity | GSTZ1,CLIC2,GPX1,LTC4S,GPX2,GPX1A,GPX1B,MGST2,GRX2,GPX3 |
| glutathione transferase activity | MGST2,GSTT2B,GSTO1,GSTP2,GSTM4,GDAP1,GSTA4,MGST3,GSTA,EEF1G |
Interacting Protein
GSTT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTT1.
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References
- Kekik, C; Yonal, I; et al. THE IMPACT OF DONOR SPECIFIC ANTI-HLA AND ANTI-GSTT1 ANTIBODIES ON THE OUTCOME OF ALLOGENEIC STEM CELL TRANSPLANTATION. TISSUE ANTIGENS 84:56-57(2014).
- Aguilera, I; Sousa, JM; et al. Clinical relevance of GSTT1 mismatch in solid organ and hematopoietic stem cell transplantation. HUMAN IMMUNOLOGY 74:1470-1473(2013).
