GSTO2
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Official Full Name
glutathione S-transferase omega 2 -
Overview
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GSTO2;glutathione S-transferase omega 2;glutathione S-transferase omega-2;bA127L20.1;Glutathione S transferase like protein;Glutathione S transferase omega 2;GSTO 2;GSTO-2;GSTO2_HUMAN;glutathione-S-transferase-like protein;bA127L20.1 (novel glutathione-S-transferase)
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GSTO2-15855H | Recombinant Human GSTO2, His-tagged | E.coli | Human | His | 1-243aa |
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| GSTO2-1759Z | Recombinant Zebrafish GSTO2 | Mammalian Cells | Zebrafish | His |
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| GSTO2-1961H | Recombinant Human Glutathione S-Transferase Omega 2, His-tagged | E.coli | Human | His |
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| GSTO2-1996R | Recombinant Rhesus monkey GSTO2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| GSTO2-4426H | Recombinant Human GSTO2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GSTO2-5710HCL | Recombinant Human GSTO2 293 Cell Lysate | HEK293 | Human | Non |
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| GSTO2-1817R | Recombinant Rhesus Macaque GSTO2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| GSTO2-1817R-B | Recombinant Rhesus Macaque GSTO2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| GSTO2-3229H | Recombinant Human GSTO2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| GSTO2-3366HF | Recombinant Full Length Human GSTO2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 243 amino acids |
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Involved Pathway
GSTO2 involved in several pathways and played different roles in them. We selected most pathways GSTO2 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione conjugation | GGT6,GSTK1,AKR1A1,GGTLC1 |
| Chemical carcinogenesis | UGT1A6,UGT2B15,CYP2C50,CYP2C70,GSTA2,CYP2C9,ARNT,CYP3A4,UGT2A2,GSTT2 |
| Metabolism of vitamins and cofactors | SLC19A2,SLC25A16,NAMPT,CYB5A,GPHNA,LOC100686744,CBLC-1,SLC5A6B,KCNG4,ELA2L |
| Metabolism | SLC25A11,NUBP1,COX11,DPYS,ADK,SACM1L,CYP4T8,SLC44A5B,RHAG,NQO1 |
| Biological oxidations | CYP4F22,CYP2C18,UGT1B7,CYP19A1,CYP8B2,FDX1,CYP2K16,GGTLC1,BPNT1,CYP2R1 |
| Glutathione metabolism | GPX1,ANPEP,GPX4,GPX4A,MGST2,GPX1A,GSTA1,MGST1.1,GGT5,GSTM1 |
| Drug metabolism - cytochrome P450 | ADH1C,CYP2B6,ADH1B,CYP2C8,CYP2A6,ADH6,CYP2C19,CYP2C9,CYP2E1,ADH7 |
| Metabolism of water-soluble vitamins and cofactors | SLC2A3,SLC5A6A,GPHN,GPHNA,SLC25A32A,SLC23A2,PDZD11,CTRC,SLC5A6B,MOCOS |
Protein Function
GSTO2 has several biochemical functions, for example, glutathione dehydrogenase (ascorbate) activity,glutathione transferase activity,methylarsonate reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTO2 itself. We selected most functions GSTO2 had, and list some proteins which have the same functions with GSTO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTA4,GSTA2,GSTT1B,GSTP2,EEF1G,LTC4S,GSTAL,GSTM1,HPGDS,GSTO1 |
| glutathione dehydrogenase (ascorbate) activity | GSTO1 |
| oxidoreductase activity | RYROXD1,CBR2,PHF2,RDH13,CYP3A4,SCCPDHB,MPX,DHRS3A,CREG1,FADS2 |
| protein binding | C1orf109,ANK2,PLOD3,PWWP2B,SH3GLB1,ARPC4,NFKBID,UNC13A,RADIL,IVL |
| methylarsonate reductase activity | GSTO1 |
Interacting Protein
GSTO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTO2.
TFAP2A;MUM1
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References
- Glisic, B; Mihaljevic, I; et al. Characterization of glutathione-S-transferases in zebrafish (Danio rerio). AQUATIC TOXICOLOGY 158:50-62(2015).
- Azizian-Farsani, F; Rafiei, G; et al. Impact of Sodium Arsenite on Chromosomal Aberrations With Respect to Polymorphisms of Detoxification and DNA Repair Genes. INTERNATIONAL JOURNAL OF TOXICOLOGY 33:518-522(2014).
