GSTA4
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Official Full Name
glutathione S-transferase alpha 4 -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinsons disease, Alzheimers disease, cataract formation, and atherosclerosis. -
Synonyms
GSTA4;glutathione S-transferase alpha 4;glutathione S transferase A4;glutathione S-transferase A4;DKFZp686D21185;Glutathione S alkyltransferase A4;Glutathione S aralkyltransferase A4;Glutathione S aryltransferase A4;Glutathione S transferase A4 4;Glutathione S transferase alpha 4;Glutathione S-transferase A4-4;Glutathione transferase A4 4;GST class alpha member 4;GST class-alpha member 4;GSTA4 4;GSTA4_HUMAN;GTA4;OTTHUMP00000016624;OTTHUMP00000016625;S (hydroxyalkyl)glutathione lyase A4;glutathione transferase A4-4;glutathione S-aryltransferase A4;glutathione S-alkyltransferase A4;glutathione S-aralkyltransferase A4;S-(hydroxyalkyl)glutathione lyase A4;GSTA4-4
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- CHO
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Flag
- Non
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
GSTA4 involved in several pathways and played different roles in them. We selected most pathways GSTA4 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | CYP2C54,UGT2B7,CYP3A25,GSTM2,AHA-1,SULT1A4,GSTM3,CYP2C39,ADH7,GSTT1 |
| Metabolism of xenobiotics by cytochrome P | UGT2B7,UGT1A6B,CBR2,GSTP1,CBR3,UGT1AB,UGT2A1,UGT1A6A,UGT1A6,GSTA2 |
| Glutathione metabolism | GPX6,GSTM6,PGD,GGT5,GSTA3,GSTM4,GSTA,GSTA2,IDH1,LAP3 |
| Drug metabolism - cytochrome P | AOX1,UGT2B7,GSTM6,GSTM,UGT1A1,GSTA,GSTT1,GSTAL,UGT1A6A,FMO2 |
Protein Function
GSTA4 has several biochemical functions, for example, glutathione transferase activity,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA4 itself. We selected most functions GSTA4 had, and list some proteins which have the same functions with GSTA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | LTC4S,GDAP1L1,GSTA3,GRX2,GDAP1,GSTT2,GSTO2,GSTK1,GSTT1B,HPGDS |
| protein homodimerization activity | CPNE1,CREB3,SLC51A,NR2C1,PCYT1A,LRRK2,LGALS6,TGFB2,HRSP12,SLC6A4 |
| protein binding | ZNF193,RASGRP3,MAP4K4,NUP35,CCER1,EFTUD2,LIPT2,HRAS,TRIM67,ZBTB24 |
Interacting Protein
GSTA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTA4.
GSTA2;C2orf50
Resources
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References
- Strom, M; Al Nimer, F; et al. Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons. NEUROMOLECULAR MEDICINE 14:15-29(2012).
- Yang, YS; Sharma, R; et al. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. ACTA BIOCHIMICA POLONICA 50:319-336(2003).
