GSTA3
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Official Full Name
glutathione S-transferase alpha 3 -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. -
Synonyms
GSTA3;glutathione S-transferase alpha 3;glutathione S transferase A3;glutathione S-transferase A3;GST class-alpha member 3;glutathione S-transferase A3-3;glutathione S-aryltransferase A3;glutathione S-alkyltransferase A3;glutathione S-aralkyltrans
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Cynomolgus
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GSTA3 involved in several pathways and played different roles in them. We selected most pathways GSTA3 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of xenobiotics by cytochrome P | ADH1,ALDH3B1,MGST3,GSTA2,CBR2,GSTM,GSTA1,GSTP1,SULT2A1,EPHX1 |
| Chemical carcinogenesis | GSTT1,SULT1A1,UGT1A3,ADH1C,ADH2-2,CYP2C38,AKR1C2,GSTK1,GSTA2,CYP3A7-CYP3AP1 |
| Glutathione metabolism | IDH2,GSTP2,GPX2,MGST1.1,GSTA2,GGCTB,GSTM4,GCLC,GGCTA,GGT7 |
| Drug metabolism - cytochrome P | MAOA,GSTM7,UGT1A6,UGT1A1,GSTM6,FMO4,MGST1.1,GSTA2,GSTM5,MGST2 |
Protein Function
GSTA3 has several biochemical functions, for example, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA3 itself. We selected most functions GSTA3 had, and list some proteins which have the same functions with GSTA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTT1,GSTM3,GSTM5,GSTT2B,EEF1G,GSTM6,GSTA1,GSTM,GSTA2,GSTM1 |
Interacting Protein
GSTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTA3.
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