GRPEL1
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Official Full Name
GrpE-like 1, mitochondrial (E. coli) -
Overview
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. -
Synonyms
GRPEL1;GrpE-like 1, mitochondrial (E. coli);grpE protein homolog 1, mitochondrial;FLJ25609;HMGE;GREPEL 1;GREPEL1;GrpE like 1;GrpE like 1 mitochondrial;GrpE like protein cochaperone;GrpE protein homolog 1 mitochondrial;GRPE1_HUMAN;GRPEL 1;Mt GrpE#1;Mt-GrpE#1;GrpE-like protein cochaperone
Recombinant Proteins
- Chicken
- Rhesus macaque
- Rat
- Human
- Zebrafish
- Cynomolgus
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
Involved Pathway
GRPEL1 involved in several pathways and played different roles in them. We selected most pathways GRPEL1 participated on our site, such as Metabolism of proteins,Mitochondrial protein import, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRPEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial protein import | TIMM17B,TIMM13,TIMM44,MTX2,SLC25A12,CHCHD4,TIMM50,DNAJC19,TIMM9,TIMM17A |
| Metabolism of proteins | ARSE,ARSI,ATPBD4,TIMM44,SEC63,TIMM10,ST6GALNAC2,SEMG1,PFDN2,NAT8B |
Protein Function
GRPEL1 has several biochemical functions, for example, adenyl-nucleotide exchange factor activity,chaperone binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRPEL1 itself. We selected most functions GRPEL1 had, and list some proteins which have the same functions with GRPEL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chaperone binding | DNAJC3,STIP1,ATP1A3,RNF207,CXorf41,PACRG,DNAJB1,DNAJB6,PFDN4,BAG2 |
| unfolded protein binding | DNAJB1A,HSPE1,CLPXA,CLPX,TTC1,PFDN6,DNAJB11,PFDN4,DNAJA2L,ERO1LB |
| protein homodimerization activity | GPD1B,CIDEA,SMAD4,PRPS1L1,GTF2A2,CUBN,GYS2,ADAM10,HOGA1,MCL1 |
| adenyl-nucleotide exchange factor activity | SIL1,GRPEL2,PFN2,HSPBP1,PFN1 |
Interacting Protein
GRPEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRPEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRPEL1.
HLA-B;VHL;EIF6;PRKAB1;tsr;NS1;US11;IFIT1;ATF2;Nedd1;PPP2R2B;ICT1;EBNA-LP;Bag2
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References
- Yan, J; Takahashi, T; et al. Combined linkage analysis and exome sequencing identifies novel genes for familial goiter. JOURNAL OF HUMAN GENETICS 58:366-377(2013).
- Amick, J; Schlanger, SE; et al. Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. PROTEIN SCIENCE 23:833-842(2014).
