GRIN1
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Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1 -
Overview
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] -
Synonyms
GRIN1;glutamate receptor, ionotropic, N-methyl D-aspartate 1;NR1;MRD8;GluN1;NMDA1;NMDAR1;glutamate receptor ionotropic, NMDA 1;NMD-R1;glutamate [NMDA] receptor subunit zeta 1;glutamate [NMDA] receptor subunit zeta-1;N-methyl-D-aspartate receptor subunit NR1;N-methyl-D-aspartate receptor channel, subunit zeta-1
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- N-6xHis
- N-10xHis
- His&Myc
- Flag
- GST
Involved Pathway
GRIN1 involved in several pathways and played different roles in them. We selected most pathways GRIN1 participated on our site, such as Ras signaling pathway,Rap signaling pathway,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | RASAL3,CALML3,FGF2,SHC4,PIK3CD,ANGPT2,RASA1,RHOA,PLD2,NGFR |
| Huntingtons disease | UQCR10,HDAC1,COX4I2,REST,TAF4B,BBC3,DNAH14,NDUFA11,NDUFC2-KCTD14,TP53 |
| Neuroactive ligand-receptor interaction | CALCR,FPR2,GRM8B,CHRM5A,TAAR7B,GRIA4,TRHR2,LEPB,NPY4R,TAAR1B |
| Calcium signaling pathway | PLCD3,GRIN2A,PLCZ1,HTR2CL1,HRH2,P2RX4A,RYR1B,PRKCG,ATP2B3B,CACNA1D |
| Rap signaling pathway | FGFR2,RAF1,PARD3,FPR1,INS2,TEK,ITGA2B,KITLG,THBS1,MAPK13 |
| Alzheimers disease | NDUFB6,NDUFA13,CALM4,CASP12,ADAM10,LRP1,SDHC,MME,IL1B,NAE1 |
| Amyotrophic lateral sclerosis (ALS) | TNFRSF1A,PPP3CB,GRIA1,CYCS,MAP3K5,PPP3CC,NEFH,NEFL,PPP3R2,BAD |
| Cocaine addiction | CREB5,GRIN2B,DRD2,GNAI3,NFKB1,GRIN2A,CDK5,SLC18A2,PRKACA,GRIN3B |
| Glutamatergic synapse | Adcy4,SHANK3,GNGT1,PLA2G4F,PRKACB,ADRBK2,GNB3,HOMER3,SLC17A7,GNG13 |
Protein Function
GRIN1 has several biochemical functions, for example, contributes_to NMDA glutamate receptor activity,contributes_to calcium channel activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN1 itself. We selected most functions GRIN1 had, and list some proteins which have the same functions with GRIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutamate binding | GRIN2A,GRM7,CPS1,GCLC,SLC1A1,GAD2,GLUL,GRIK1,SLC1A3 |
| glutamate receptor binding | SYNDIG1,GRIN2A,CAMK2A,PLCG1 |
| protein heterodimerization activity | PAFAH1B2,ALX4,TGFB1,ALG2,H2AFB2,HIST1H2BD,RELA,TYRO3,CHRAC1,H3F3A |
| glycine binding | GLRA2,GNMT,GRIN3B,GRIN3A,GSS,GLDC,GLRA4A,GLRA4B,GRIN2B,SRR |
| calcium ion binding | MMP10,MMP14,PKD2,PCDH2G16,PCDH1A3,EGF,PRRG1,PCDHGB2,ITGB1BP2,KCNIP3B |
| enzyme binding | HIF1A,TAF10,LAMP1,HIST1H2AN,PIAS1,GSTM4,CSF3,MAP2K7,PLSCR4,RPS2 |
| contributes_to calcium channel activity | GRIN3B,GRIN2A |
| voltage-gated cation channel activity | GRIN2A,HVCN1,PKD2,GRIK1 |
| calmodulin binding | TRPV1,AKAP5,ITPKC,MYO3A,TRPV5,CNN3,OBSCN,TTN,MARCKSB,ASPM |
Interacting Protein
GRIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN1.
Tiam1;Tiam2;PLCB4;ERBB4
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References
- Contreras-Vallejos, E; Utreras, E; et al. Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(-/-) Mice. PLOS ONE 9:-(2014).
- Lieberman, R; Levine, ES; et al. Pilot Study of iPS-Derived Neural Cells to Examine Biologic Effects of Alcohol on Human Neurons In Vitro. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:1678-1687(2012).
