GRIK4
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Official Full Name
glutamate receptor, ionotropic, kainate 4 -
Overview
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. -
Synonyms
GRIK4;glutamate receptor, ionotropic, kainate 4;GRIK;glutamate receptor, ionotropic kainate 4;GluK4;KA1;glutamate receptor KA1;glutamate receptor KA-1;excitatory amino acid receptor 1;EAA1
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRIK4-2698R | Recombinant Rat GRIK4 Protein | Mammalian Cell | Rat | His |
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| GRIK4-29879TH | Recombinant Human GRIK4 | Wheat Germ | Human | Non | 110 amino acids |
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| GRIK4-7267M | Recombinant Mouse GRIK4 Protein | Mammalian Cell | Mouse | His |
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| GRIK4-2352R | Recombinant Rat GRIK4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GRIK4-2352R-B | Recombinant Rat GRIK4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRIK4-3929M | Recombinant Mouse GRIK4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GRIK4-3929M-B | Recombinant Mouse GRIK4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRIK4-5340H | Recombinant Human GRIK4 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GRIK4 involved in several pathways and played different roles in them. We selected most pathways GRIK4 participated on our site, such as Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamatergic synapse | GRIK5,GRIN1,PLD2,ITPR1,PLD1,GRIK3,PRKCA,GRIK1,SLC1A6,MAPK3 |
| Neuroactive ligand-receptor interaction | MC5RB,TAAR4,IL12,CHRNB3,HTR4,C5AR1,P2RX5,GABRB3,PTH1R,ADCYAP1R1A |
Protein Function
GRIK4 has several biochemical functions, for example, extracellular-glutamate-gated ion channel activity,kainate selective glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIK4 itself. We selected most functions GRIK4 had, and list some proteins which have the same functions with GRIK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kainate selective glutamate receptor activity | GRIK3,GRIK1,GRIK2,GRIK5 |
| extracellular-glutamate-gated ion channel activity | GRIK1,GRIN1B,GRIA4B,GRIK5,GRIN2BB,GRIA2B,GRID2,GRIA4,GRIN1,GRIA2A |
Interacting Protein
GRIK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIK4.
Resources
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References
- Trippe, J; Steinke, K; et al. Autoantibodies to Glutamate Receptor Antigens in Multiple Sclerosis and Rasmussen's Encephalitis. NEUROIMMUNOMODULATION 21:189-194(2014).
- Balasuriya, D; Goetze, TA; et al. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements. JOURNAL OF BIOLOGICAL CHEMISTRY 288:-(2013).
