GPR77
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Official Full Name
G protein-coupled receptor 77 -
Overview
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the;complement cascade that participate in host defense. In the case of inappropriate complement activation,;anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM;113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 (PubMed;16204243)). -
Synonyms
GPR77;G protein-coupled receptor 77;C5a anaphylatoxin chemotactic receptor C5L2;C5L2;G-protein coupled receptor 77;G protein-coupled receptor C5L2;GPF77
Recombinant Proteins
- Human
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPR77-13488H | Recombinant Human GPR77, GST-tagged | E.coli | Human | GST | 1-115a.a. | |
| GPR77-19478H |
Active Recombinant Human GPR77 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| GPR77-5778HCL | Recombinant Human GPR77 293 Cell Lysate | HEK293 | Human | Non |
|
|
| GPR77-5263H | Recombinant Human GPR77 Protein | Wheat Germ | Human | Non |
|
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| GPR77-5264H | Recombinant Human GPR77 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| GPR77-5632HF | Recombinant Full Length Human GPR77 Protein | In Vitro Cell Free System | Human | Full L. 372 amino acids |
|
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| GPR77-5634HF | Recombinant Full Length Human GPR77 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 337 amino acids |
|
Involved Pathway
GPR77 involved in several pathways and played different roles in them. We selected most pathways GPR77 participated on our site, such as Class A/1 (Rhodopsin-like receptors),GPCR ligand binding,GPCRs, Class A Rhodopsin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR77 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Other | V1RA8,EMR2,VMN1R46,OR3A4P,VMN1R45,SETD6,GPR132,VMN1R40,VMN1R44,GPR183 |
| GPCRs, Class A Rhodopsin-like | PTGDR2,CNR2,GPR75,GPR31,SSTR3,CNR1,CYSLTR1,SSTR5,HRH3,SSTR2 |
| GPCR ligand binding | RHOL,NPS,PENKB,GNB5B,CCL35.1,ADRA2B,LPAR5A,GPRC6A,OPN4A,OPN4.1 |
| Signaling by GPCR | RAMP2,PTHRP2,NTS,CCRL2,OXGR1,PENKB,OR52J3,GPR39,PNOCB,PLEKHG2 |
| Signal Transduction | SOX13,FMNL1,RGS11,TAC1,RNF43,TAGAP1,CCNT2B,STARD8,NPSR1,RHOF |
| Peptide ligand-binding receptors | CCBP2,PENKB,PROK1,NMB,NPS,SST,CX3CR1,XK,KISS1,GAL |
| Class A/1 (Rhodopsin-like receptors) | INSL5,CCBP2,GPR37L1,GPR132B,POMCB,PENKA,CCR3,NMBB,KEL,SSTR2 |
Protein Function
GPR77 has several biochemical functions, for example, C5a anaphylatoxin receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR77 itself. We selected most functions GPR77 had, and list some proteins which have the same functions with GPR77. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FCN1,DNPEP,ADORA2A,RAD51L3,FCRL4,FLI1,LRRC4C,CARF,SRF,DHPS |
| C5a anaphylatoxin receptor activity | C5AR1 |
Interacting Protein
GPR77 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR77 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR77.
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References
- David, J; Barkema, HW; et al. Gene-expression profiling of calves 6 and 9 months after inoculation with Mycobacterium avium subspecies paratuberculosis. VETERINARY RESEARCH 45:-(2014).
- Hu, SH; Feng, YZ; et al. VirD: A Virion Display Array for Profiling Functional Membrane Proteins. ANALYTICAL CHEMISTRY 85:8046-8054(2013).
