GPC6
-
Official Full Name
glypican 6 -
Overview
The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans, and they have been implicated in the control of cell growth and cell division. The glypican encoded by this gene is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. -
Synonyms
GPC6;glypican 6;glypican-6;glypican proteoglycan 6;OMIMD1;MGC126288
Recombinant Proteins
- Human
- E.coli
- Mammalian cells
- HEK293
- Yeast
- His
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GPC6-13417H | Recombinant Human GPC6, His-tagged | E.coli | Human | His | 213-278a.a. | |
| GPC6-5629H |
Active Recombinant Human Glypican 6, His-tagged
|
Mammalian cells | Human | His | 24-354;355-527 a.a. |
|
| GPC6-5811HCL | Recombinant Human GPC6 293 Cell Lysate | HEK293 | Human | Non |
|
|
| GPC6-1403H | Recombinant Human GPC6 Protein (24-529 aa), His-tagged | Yeast | Human | His | 24-529 aa |
|
| GPC6-2987H | Recombinant Human GPC6 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 24-529aa |
|
| GPC6-3058H | Recombinant Human GPC6 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| GPC6-3058H-B | Recombinant Human GPC6 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
Involved Pathway
GPC6 involved in several pathways and played different roles in them. We selected most pathways GPC6 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,Chondroitin sulfate/dermatan sulfate metabolism,Defective B3GALT6 causes EDSP2 and SEMDJL1, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | GPC5,AGRN |
| Defective EXT2 causes exostoses 2 | GPC5,AGRN |
| Disease | AP2M1,HEYL,OPN1MW,OPN1MW2,RPL35,PDCD6IP,NUPL2,GPC5,AP1B1,KPNA4 |
| A tetrasaccharide linker sequence is required for GAG synthesis | VCAN,B3GAT2,B4GALT7,BGN,BCAN,CSPG4,GPC5,BGNB,CSPG5,GPC1A |
| Defective B3GAT3 causes JDSSDHD | BCAN,BGN,CSPG4,GPC5,CSPG5,AGRN,VCAN,DCN,NCAN |
| Defective B4GALT7 causes EDS, progeroid type | CSPG4,BCAN,DCN,CSPG5,BGN,GPC5,VCAN,AGRN,NCAN |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | BGN,BCAN,AGRN,NCAN,GPC5,CSPG4,DCN,CSPG5,VCAN |
| Chondroitin sulfate/dermatan sulfate metabolism | BGNB,GPC1B,B3GAT2,Gpc2,AGRN,BCAN,CHST14,CSPG4,BGNA,DCN |
Protein Function
GPC6 has several biochemical functions, for example, heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPC6 itself. We selected most functions GPC6 had, and list some proteins which have the same functions with GPC6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparan sulfate proteoglycan binding | HPSE2,GPC6A,AZU1,Gpc2,CFH,AGRN,GPC3,FST,HRG,Itgam&Itgb2 |
Interacting Protein
GPC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPC6.
GABARAP;GABARAPL2;GABARAPL1
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References
- Gromova, P; Ralea, S; et al. Kit K641E oncogene up-regulates Sprouty homolog 4 and Trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:1536-1548(2009).
