GP1BB
-
Official Full Name
glycoprotein Ib (platelet), beta polypeptide -
Overview
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene. -
Synonyms
GP1BB;glycoprotein Ib (platelet), beta polypeptide;platelet glycoprotein Ib beta chain;CD42c;Antigen CD42b beta;CD_antigen=CD42c;Flags: Precursor;Glycoprotein Ib (platelet) beta polypeptide;Glycoprotein Ib beta polypeptide;GP Ib beta;GP Ib beta subunit;GP1bbeta;GPIb beta;Nuclear localization signal deleted in velocardiofacial syndrome;Platelet glycoprotein Ib beta polypeptide;GPIb-beta;GP-Ib beta;antigen CD42b-beta;BS;GPIBB;BDPLT1
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Mus musculus
- Papio cynocephalus (Yellow baboon)
- HEK293
- Mammalian Cell
- E.coli
- Human Cell
- In vitro E. coli expression system
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- His&T7
- Fc
- Non
- His&Fc&Avi
- His&Myc&SUMO
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GP1BB-2247H | Recombinant Human GP1BB protein, His-tagged | HEK293 | Human | His | Met1-Cys147 | |
| GP1BB-15H | Active Recombinant Human GP1BB Protein (26-147aa), C-His-tagged | HEK293 | Human | His | 26-147 aa | |
| GP1BB-2625R | Recombinant Rat GP1BB Protein | Mammalian Cell | Rat | His |
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| Gp1bb-5729M | Recombinant Mouse Gp1bb protein, His & T7-tagged | E.coli | Mouse | His&T7 | Phe53~Arg176 |
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| Gp1bb-5730R | Recombinant Rat Gp1bb protein, His & T7-tagged | E.coli | Rat | His&T7 | Ala52~His164 |
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| GP1BB-7296Z | Recombinant Zebrafish GP1BB | Mammalian Cell | Zebrafish | His |
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| Gp1bb-8805R | Recombinant Rat Gp1bb protein(Met1-Cys147), hFc-tagged | HEK293 | Rat | Fc | 1-147 a.a. |
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| GP1BB-1243RCL | Recombinant Rat GP1BB cell lysate | Human Cell | Rat | Non |
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| GP1BB-2588HCL | Recombinant Human GP1BB cell lysate | Human Cell | Human | Non |
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| GP1BB-2280R | Recombinant Rat GP1BB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GP1BB-2280R-B | Recombinant Rat GP1BB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GP1BB-2723H | Recombinant Human GP1BB Full Length Transmembrane protein (26-206 aa), His-SUMO-Myc-tagged | In vitro E. coli expression system | Human | His&Myc&SUMO | Full L. 26-206aa |
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| GP1BB-4206H | Recombinant Human GP1BB Protein (Met1-Cys147), C-His tagged | Mammalian cells | Human | His | Met1-Cys147 |
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| GP1BB-5132H | Recombinant Human GP1BB Protein | Wheat Germ | Human | Non |
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| GP1BB-5463HF | Recombinant Full Length Human GP1BB Protein | In Vitro Cell Free System | Human | Full L. 738 amino acids |
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| GP1BB-674H | Recombinant Human GP1BB protein, hFc-tagged | HEK293 | Human | Fc | Pro27-Cys147 |
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| Gp1bb-8855M | Recombinant Mouse Gp1bb protein, hFc-tagged | HEK293 | Mouse | Fc | Pro27-Cys147 |
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| RFL15947MF | Recombinant Full Length Mouse Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (27-206) |
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| RFL22769PF | Recombinant Full Length Papio Cynocephalus Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His-Tagged | E.coli expression system | Papio cynocephalus (Yellow baboon) | His | Full L. Full Length of Mature Protein (27-208) |
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| RFL7798HF | Recombinant Full Length Human Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His&Myc-Tagged | E.coli expression system | Human | His&Myc | Full L. Full Length of Mature Protein (26-206aa) |
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Involved Pathway
GP1BB involved in several pathways and played different roles in them. We selected most pathways GP1BB participated on our site, such as ECM-receptor interaction,Platelet activation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP1BB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | COL2A1B,THBS4B,THBS4,ITGB7,COL27A1,LAMA3,ITGB6,COL6A4,ITGA8,ITGB3 |
| Hematopoietic cell lineage | IL5RA,MS4A1,IL11,CD8A,CR2,CR1,HLA-DRB5,ITGB3,CSF3R,EPOR |
| Platelet activation | MYLK2,MYLK3,VASP,LCP2,PLCB1,PLA2G4D,PLCG2,PIK3R5,MAPK1,MYLK |
Protein Function
GP1BB has several biochemical functions, for example, protein binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP1BB itself. We selected most functions GP1BB had, and list some proteins which have the same functions with GP1BB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FANCI,PHAX,GRAMD3,INPPL1,TXNDC12,SSX2IP,THRAP3,TSPYL4,MKNK2,C5orf24 |
| transmembrane signaling receptor activity | GLP1R,DARC,OR4D6,OR4D2,GPR98,ADCYAP1R1A,FZD7B,CD27,EMR4,CD79A |
Interacting Protein
GP1BB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP1BB here. Most of them are supplied by our site. Hope this information will be useful for your research of GP1BB.
GP1BA;ezrA;GP9;VCAM1
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References
- Morales, LD; Martin, C; et al. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 4:417-425(2006).
- Peng, YD; Berndt, MC; et al. The alpha 1 helix beta 13 strand spanning Leu214 to Val229 of platelet glycoprotein Ib alpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. BLOOD 104:3971-3978(2004).
