GNG11
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Official Full Name
guanine nucleotide binding protein (G protein), gamma 11 -
Overview
This gene is a member of the guanine nucleotide-binding protein (G protein) gamma family and encodes a lipid-anchored, cell membrane protein. As a member of the heterotrimeric G protein complex, this protein plays a role in this transmembrane signaling system. This protein is also subject to carboxyl-terminal processing. Decreased expression of this gene is associated with splenic marginal zone lymphomas. -
Synonyms
GNG11;guanine nucleotide binding protein (G protein), gamma 11;guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11;G protein gamma 11 subunit;GNGT11;guanine nucleotide binding protein G(I)/G(S)/G(O) gamma 11 subunit;Guanine nucleotide binding protein G;Guanine nucleotide binding protein gamma 11;IG;Osubunit gamma 11 precursor;SG;OTTHUMP00000162594;G protein gamma-11 subunit;guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-11 subunit
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GNG11 involved in several pathways and played different roles in them. We selected most pathways GNG11 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNG11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | NFKB1,Kitl,PLCB4,PTEN,FZD6,GNB4,PRKACG,ETS1,WNT16,HRAS |
| Glutamatergic synapse | GRIN1,PRKACG,GRM1,SLC1A1,GLS,PLCB3,HOMER3,SLC17A6,PPP3R2,SLC1A6 |
| Ras signaling pathway | PDGFD,SHC1,GRIN1,NRAS,KRAS,PAK2,PDGFB,MLLT4,SHC3,ANGPT4 |
| PIK-Akt signaling pathway | YWHAG,PDGFRA,GNG5,FGFR4,COL24A1,IL2RG,Itga10&Itgb1,KITLG,TCL1A,IBSP |
| Dopaminergic synapse | SLC18A2,KCNJ6,PPP2R5E,PPP2R5C,PPP2R2C,DRD2,PPP2R2B,CAMK2A,MAPK12,GNG5 |
| Alcoholism | ATF4,CALML3,CREB3L2,GNB2,CALM2,HIST1H2BK,HIST1H2AG,CREB5,HIST1H2BQ,CREB3L4 |
| GABAergic synapse | GABRQ,GLUL,GNG4,GABRA2,PRKACA,GNAI3,NSF,GNG8,GNAI1,GABARAP |
| Cholinergic synapse | CREB5,AKR1C1,ITPR1,GNGT1,MAP2K1,KCNJ2,PIK3R1,GNG13,CHRM1,MAPK1 |
| Retrograde endocannabinoid signaling | GNG5,GNGT1,GNGT2,PRKACB,GNG3,GABRE,GABRB3,PLCB2,GRM1,SLC17A8 |
Protein Function
GNG11 has several biochemical functions, for example, GTPase activity,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNG11 itself. We selected most functions GNG11 had, and list some proteins which have the same functions with GNG11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | MAPKAPK2B,TAAR12B,PLK2,STMN1,OLFR18,OLFR15,GPR141,CRKL,TICAM2,SUFU |
| GTPase activity | ARL1,EIF5B,GNL1,GNAO1B,GUF1,MXG,RAB1,GSPT1L,EEF2A.2,RAB3AA |
Interacting Protein
GNG11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNG11 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNG11.
SMURF1;ZHX1;AMOTL2
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References
- Fang, F; Pan, J; et al. Identification of Potential Transcriptomic Markers in Developing Ankylosing Spondylitis: A Meta-Analysis of Gene Expression Profiles. Biomed Research International :-(2015).
- Xue, DB; Lu, M; et al. Screening for transcription factors and their regulatory small molecules involved in regulating the functions of CL1-5 cancer cells under the effects of macrophage- conditioned medium. ONCOLOGY REPORTS 31:1323-1333(2014).
