GNE
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Official Full Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase -
Overview
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. -
Synonyms
GNE;glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase;IBM2, UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase;bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase;Uae1;IBM2;2310066H07Rik;Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase;DMRV;ManAc kinase;N acylmannosamine kinase;NM;RP23-209M8.6;UDP GlcNAc 2 epimerase;UDP GlcNAc 2 epimerase/ManAc kinase;Uridine diphosphate N acetylglucosamine 2 epimerase;N-acylmannosamine kinase;UDP-GlcNAc-2-epimerase/ManAc kinase;UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase;UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase;GLCNE
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNE-13359H | Recombinant Human GNE, His-tagged | E.coli | Human | His | 376-722a.a. | |
| GNE-11130Z | Recombinant Zebrafish GNE | Mammalian Cells | Zebrafish | His |
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| GNE-2605R | Recombinant Rat GNE Protein | Mammalian Cells | Rat | His |
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| GNE-3081C | Recombinant Chicken GNE | Mammalian Cells | Chicken | His |
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| GNE-94H | Recombinant Human GNE, His-tagged | HEK293 | Human | His |
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| GNE-5858HCL | Recombinant Human GNE 293 Cell Lysate | HEK293 | Human | Non |
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| GNE-2260R | Recombinant Rat GNE Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GNE-2260R-B | Recombinant Rat GNE Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GNE-5061H | Recombinant Human GNE Protein, GST-tagged | Wheat Germ | Human | GST |
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| GNE-5383HF | Recombinant Full Length Human GNE Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 722 amino acids |
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| GNE-6082H | Recombinant Human GNE Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
GNE involved in several pathways and played different roles in them. We selected most pathways GNE participated on our site, such as Amino sugar and nucleotide sugar metabolism,Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | OAT,PLA2G5,PIGH,COQ7,cysH,POLR2C,QDPRB1,LIAS,FUT7,HMGCS2 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | MPDU1,ST3GAL3A,NANP,ST6GAL2B,MPDU1A,NEU4,ALG14,ST8SIA2,DPAGT1,ST8SIA3 |
| Post-translational protein modification | SEC22A,MPDU1A,EID3,MIA3,LMAN2L,UBA2,TMED2,NAPB,SMC6,MUC13 |
| Asparagine N-linked glycosylation | LMAN2,GORASP1,DAD1,PPP6R1,TRAPPC10,DDOST,ST8SIA2,TRAPPC2,TRAPPC2L,ANKRD28 |
| Amino sugar and nucleotide sugar metabolism | NAGK,CHIA.4,CHIA.2,UAP1L1,RENBP,HKDC1,UAP1,GMPPA,GPIB,PMM1 |
| Synthesis of substrates in N-glycan biosythesis | SLC35A1,ST6GAL2B,ST6GALNAC1.2,ST8SIA3,ST6GALNAC2 |
| Sialic acid metabolism | ST8SIA3,ST6GALNAC2,ST6GALNAC1.2,NANP,SLC35A1,ST6GAL2B |
| Metabolism of proteins | HDGF,TOMM20,PFDN6,ST6GAL2B,TOMM40,ADAMTS1,LTF,GFER,GPR116,SUMF2 |
Protein Function
GNE has several biochemical functions, for example, ATP binding,N-acylmannosamine kinase activity,UDP-N-acetylglucosamine 2-epimerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNE itself. We selected most functions GNE had, and list some proteins which have the same functions with GNE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | B3GNT1,ZNF800B,PDCD2,ZNF831,ZNF280C,OVOL2,MGAT5B,CBFA2T2,GTF3A,CYP2AD2 |
| protein binding | MZT1,TH1L,C17orf81,TNS1,IFI6,STARD3,PHF8,RAD51D,CSNK1G1,SMARCA2 |
| hydrolase activity, hydrolyzing O-glycosyl compounds | CHIA.1,CHIA.4,LCTL,KIAA1161,KLB,CHIA.3,ABHD10,LCTLB,Chil3,GBE1 |
| ATP binding | MARK4,NAIP1,GLULA,UBE2D2A,CCT2,PI4K2A,ASCC3,CARNS1,DGKZ,CHD7 |
| N-acylmannosamine kinase activity | NAGK |
Interacting Protein
GNE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNE here. Most of them are supplied by our site. Hope this information will be useful for your research of GNE.
SPRY2;KRTAP5-9;KRTAP10-5;KRTAP10-7;KRTAP10-8;KRTAP10-9
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References
- Weldon, RA; Fensin, ML; et al. Total neutron emission generation and characterization for a Next Generation Safeguards Initiative spent fuel library. PROGRESS IN NUCLEAR ENERGY 80:45-73(2015).
- Broccolini, A; Mirabella, M; et al. Hereditary inclusion-body myopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:644-650(2015).
