GNAQ
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Official Full Name
guanine nucleotide binding protein (G protein), q polypeptide -
Overview
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010] -
Synonyms
GNAQ;guanine nucleotide binding protein (G protein), q polypeptide;GAQ;SWS;CMC1;G-ALPHA-q;guanine nucleotide-binding protein G(q) subunit alpha;guanine nucleotide-binding protein alpha-q
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
- Non
- Flag
- Avi
- Fc
Involved Pathway
GNAQ involved in several pathways and played different roles in them. We selected most pathways GNAQ participated on our site, such as Rap signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | PPP1R12C,PRKACA,CALM4,CACNA1DA,PTGIR,KCNMB4,PRKCH,CACNA1C,ADCY1B,PRKCBB |
| Pathways in cancer | WNT8B,IKBKG,RAC3,NTRK1,PRKCA,CCNA1,WNT4,CCDC6,MAPK9,VHL |
| Huntingtons disease | DCTN2,ATP5E,CASP8,UQCRC2,ATP5O,COX6B2,SLC25A4,COX6C,SDHD,APAF1 |
| Glutamatergic synapse | PRKCA,MAPK1,GRIN3B,GLUL,GRIK5,GNB1,ADRBK2,PRKACB,GNG2,GNGT2 |
| Serotonergic synapse | TPH1,CYP4X1,MAPK1,TPH2,HTR3B,GNG8,GNAI3,GNAI1,GNG10,HTR6 |
| Dopaminergic synapse | PPP1CB,GSK3B,GNB3,PPP2R5D,CREB3L3,DRD2,PLCB3,PPP2R5E,COMT,MAOA |
| Estrogen signaling pathway | GNAO1,CALM4,ESR2,ATF6B,HRAS,GABBR1,FOS,HSP90AB1,HSP90AA1,MAP2K1 |
| Renin secretion | REN,ACE,LOC100328615,PPP3CA,PRKG2,CLCA5,GNAS,CALML3,PLCB2,CALM1 |
| Cholinergic synapse | CHRM3,PIK3CB,PIK3R5,AKR1C1,CREB3,ACHE,PRKCB,GNB2,KCNJ2,GNAI2 |
Protein Function
GNAQ has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,GTP binding,GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAQ itself. We selected most functions GNAQ had, and list some proteins which have the same functions with GNAQ. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | AGAP2,TUBB,GPN1,DIRAS3,MFN1,TUBB2B,RAB3DB,TUBA3D,ARFRP1,RAB12 |
| type 2A serotonin receptor binding | GNA11,ARRB2 |
| GTP binding | RND1L,ARL13A,RAB5C,SEPT5A,GFM1,RP2,RAB7L1,AK3,TUBG2,RAB22A |
| protein binding | ZNF180,CDC42EP2,HSPA1A,RGS6,USP37,SNTB2,VPS33A,GOLGA3,AKAP7,FCN2 |
| signal transducer activity | ADORA2AB,HTR5AL,ILK,MIER1A,TAAR13E,OLFR493,V2RH14,RERG,CSPG4,GNB2 |
| GTPase activator activity | IQGAP3,RALBP1,ARHGEF12,PTPLAD1,HTR2B,OPHN1,ARHGAP26,LLGL2,RGS9,ARHGAP8 |
| G-protein beta/gamma-subunit complex binding | GNAO1,GNAI3,GNAT1,ADORA1,CETN2,GNAI2B,GNAL,GNA11B,GNAI2,GNA13 |
| metal ion binding | TRIM35-1,ATP2A2A,LHX8,AGMAT,LRRK1,NR2F6B,WBSCR17,TRERF1,ZNF592,ADK |
Interacting Protein
GNAQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAQ here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAQ.
RARA;ARRB1;PARP2;PECAM1;AGTR1;CXCR5;PPT1;LUM;ADHFE1;NT5C3A;pi3p;FLOT2;Myh10
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