GMPPB
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Official Full Name
GDP-mannose pyrophosphorylase B -
Overview
This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
GMPPB;GDP-mannose pyrophosphorylase B;mannose-1-phosphate guanyltransferase beta;KIAA1851;mannose-1-phosphate guanylyltransferase;GTP-mannose-1-phosphate guanylyltransferase beta
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- GST
Involved Pathway
GMPPB involved in several pathways and played different roles in them. We selected most pathways GMPPB participated on our site, such as Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GMPPB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amino sugar and nucleotide sugar metabolism | HK2,CHIA.3,GPIA,HKDC1,UAP1L1,FUK,HEXA,CYB5R4,CHIT1,GPI1 |
| Metabolic pathways | AMD1,CYP21A2,LPCAT2,ALPI.2,ctaG,ACMSD,GUK1A,CHDH,RDH10B,CYP2J6 |
| Fructose and mannose metabolism | MPI,AKR1B1L,PFKMB,Akr1b3,AKR1B10,AKR1B7,PMM1,FBP1,ALDOC,ENOSF1 |
Protein Function
GMPPB has several biochemical functions, for example, GTP binding,mannose-1-phosphate guanylyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GMPPB itself. We selected most functions GMPPB had, and list some proteins which have the same functions with GMPPB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | MB21D1,ARF4B,RAP1A,GPN1,TUBA8L2,RHOT1B,ARF3A,ERAL1,SEPT8B,RAB38 |
| protein binding | ZNF622,ETF1,AACS,C7orf59,GCET2,VSIG4,BRCA2,PPIB,RAB6A,CSNK2B |
| mannose-1-phosphate guanylyltransferase activity | GMPPAA,GMPPAB |
Interacting Protein
GMPPB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GMPPB here. Most of them are supplied by our site. Hope this information will be useful for your research of GMPPB.
GMPPA;TXNDC5;TSC22D1;Sesn2
Resources
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References
- Raphael, AR; Couthouis, J; et al. Congenital muscular dystrophy and generalized epilepsy caused by GMPPB mutations. BRAIN RESEARCH 1575:66-71(2014).
- Bertoli, M; Evangelista, T; et al. Intrafamilial heterogeneity in an alpha-dystroglycanopathy due to GDP-Mannose Pyrophosphorylase B (GMPPB) mutations. NEUROMUSCULAR DISORDERS 24:915-916(2014).
