GLYAT
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Official Full Name
glycine-N-acyltransferase -
Overview
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is;thought to be important in the detoxification of endogenous and xenobiotic acyl-CoAs. Two transcript variants;encoding different isoforms have been found for this gene. -
Synonyms
GLYAT;glycine-N-acyltransferase;glycine N-acyltransferase;ACGNAT;GAT;AAc;HRP-1(CLP);aralkyl-CoA N-acyltransferase;acyl-CoA:glycine N-acyltransferase;aralkyl acyl-CoA N-acyltransferase;aralkyl acyl-CoA:amino acid N-acyltransferase;CAT
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GLYAT involved in several pathways and played different roles in them. We selected most pathways GLYAT participated on our site, such as Amino Acid conjugation,Amino acid conjugation of benzoic acid,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLYAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP2F1,UGT1B4,CYP46A1,ADH5,SULT1ST6,PRKRA,SLC26A1,CYP2K19,ABHD14B,CYP2A13 |
| Conjugation of benzoate with glycine | GLYATL1,ACSM1,GLYATL2 |
| Amino acid conjugation of benzoic acid | GLYATL2,GLYATL1 |
| Metabolism | SLC23A2,AKR1C6,SLC26A1,COX6A1,UGT1B3,NUDT10,CYP24A1,NUDT11,CYP2K6,AZIN1 |
| Amino Acid conjugation | ACSM1,GLYATL2,GLYATL1 |
| Phase II conjugation | UGT1B2,ABHD14B,SULT1C2,SULT4A1,ABHD10,Sult2a6,AS3MT,SULT1C4,GGTLC1,SLC35B2 |
| Conjugation of salicylate with glycine | GLYATL2,GLYATL1 |
| Conjugation of carboxylic acids | GLYATL2,ACSM1,GLYATL1 |
Protein Function
GLYAT has several biochemical functions, for example, glycine N-acyltransferase activity,glycine N-benzoyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLYAT itself. We selected most functions GLYAT had, and list some proteins which have the same functions with GLYAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity, transferring acyl groups | LIPT1,DGAT2L6,NAT14,AANAT,ZDHHC16B,ZDHHC3B,DGAT1B,CHATA,GGACT.3,MBOAT4 |
| glycine N-acyltransferase activity | KEG1,GM4952,GLYATL2,GLYATL1 |
| protein binding | TNP1,CCT3,TRIM67,JUN,SEPT12,SGTA,NPBWR2,TESK1,MYH7B,NSMCE4A |
Interacting Protein
GLYAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLYAT here. Most of them are supplied by our site. Hope this information will be useful for your research of GLYAT.
KRTAP10-8;NOTCH2NL;PA;PTN;RBM48;VOPP1
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References
- Dempsey, DR; Bond, JD; et al. Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION 97:23-28(2014).
- Badenhorst, CPS; van der Sluis, R; et al. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation. EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY 9:1139-1153(2013).
