GLUL
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Official Full Name
glutamate-ammonia ligase -
Overview
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] -
Synonyms
GLUL;glutamate-ammonia ligase;GS;GLNS;PIG43;PIG59;glutamine synthetase;glutamine synthase;glutamate decarboxylase;glutamate--ammonia ligase;proliferation-inducing protein 43;cell proliferation-inducing protein 59
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Cynomolgus
- Mouse
- Chicken
- Cricetulus Griseus
- Chinese hamster
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- SUMO
- Flag
- GST
Involved Pathway
GLUL involved in several pathways and played different roles in them. We selected most pathways GLUL participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLUL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | GNB4,GNAO1,GABRQ,GNAI1,SLC6A1,GPHN,GNG11,Adcy4,GLS,GABRA4 |
| Nitrogen metabolism | CA7,CA4,Car8,GLUD1A,CA2,CA12,Car2,GLUD1B,CAHZ,CA1 |
| Glyoxylate and dicarboxylate metabolism | AGXTB,GLULB,AMT,ANI_1_2390104,MCEE,PCCA,GCSH,GRHPR,MDH1,PGP |
| Biosynthesis of amino acids | ARG1,BCAT1,TKTB,PYCRL,GOT2B,PGAM1A,GM5506,PKM,PFKP,ASL2 |
| Arginine biosynthesis | NOS2B,NOS2A,GOT2A,GLUD1B,GLULA,ACY1,GOT2B,GPT,ASL2,NOS3 |
| Alanine, aspartate and glutamate metabolism | ABAT,GFPT1,ASPA,ybaS,GAD2,GFPT2,RIMKLA,ASS1,FOLH1,GLUD2 |
| Metabolic pathways | CYP2A12,ENO1B,LDHAL6B,FUT1,DAK,IMPA1,EXT1A,NDUFB4,GAPDHS,PIGN |
| Glutamatergic synapse | GRM8,GRIK2,GNB1,PPP3R2,PPP3R1,SHANK3,PPP3CA,GRIK4,GNAQ,PLCB1 |
Protein Function
GLUL has several biochemical functions, for example, ATP binding,dynein light chain binding,glutamate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLUL itself. We selected most functions GLUL had, and list some proteins which have the same functions with GLUL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutamate-ammonia ligase activity | LGSN,GLULC,GLULA,GLULB |
| identical protein binding | PDCD6,AMOTL2,GDF5,ADIPOR2,MMP9,LEPR,MID1,FRS3,KCNJ10,SYNE1 |
| ATP binding | MAST2,ITM2C,ASNS,NIM1,FARSA,SLC27A2,MCM9,CAMKK1A,STRADA,IARS2 |
| manganese ion binding | FAM20C,PPM1B,LARGE,ABL2,PPEF1,PPM1BA,XPNPEP3,PPM1NB,NUDT16,WRN |
| magnesium ion binding | PKLR,PPM1BB,MARK2,GCLC,RPS6KA1,PRPS1,MAP3K6,ATP4A,PIF1,HACL1 |
| glutamate binding | GRIK1,GAD2,GRM7,GRIN1,SLC1A3,SLC1A1,CPS1,GCLC,GRIN2A |
| glutamate decarboxylase activity | GAD1,GAD1B,GAD2 |
Interacting Protein
GLUL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLUL here. Most of them are supplied by our site. Hope this information will be useful for your research of GLUL.
HLA-B;PIAS1;PIAS2;MT-ND5;TFAP2A;SKIL;NFKB1;UBE2I;acnA;NUDT18;RBBP6;RABEPK;nprB;scrFIAM;HIPK1;HIPK3
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References
- Mazumdar, T; Sandhu, R; et al. Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells. PLOS ONE 8:-(2013).
- Choe, JY; Yun, JY; et al. Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features. JOURNAL OF CLINICAL PATHOLOGY 68:6-11(2015).
