GLRX3
-
Official Full Name
glutaredoxin 3 -
Overview
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. -
Synonyms
GLRX3;glutaredoxin 3;thioredoxin like 2 , TXNL2;glutaredoxin-3;bA500G10.4;GLRX4;glutaredoxin 4;GRX3;GRX4;PICOT;PKC interacting cousin of thioredoxin;PKC theta interacting protein;PKCq interacting protein;Thioredoxin like protein 2;OTTHUMP00000020746;OTTHUMP00000020747;OTTHUMP00000020748;PKCq-interacting protein;thioredoxin-like protein 2;PKC-theta-interacting protein;PKC-interacting cousin of thioredoxin;TXNL2;TXNL3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- GST
- His
- T7
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GLRX3 involved in several pathways and played different roles in them. We selected most pathways GLRX3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLRX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GLRX3 has several biochemical functions, for example, electron carrier activity,iron-sulfur cluster binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLRX3 itself. We selected most functions GLRX3 had, and list some proteins which have the same functions with GLRX3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase C binding | HDAC5,TOP2B,HDAC7,DACT3,HDAC7A,TRPV4,HDAC9,PDLIM5,SDC4,C1QBP |
| poly(A) RNA binding | SARS2,MYO5A,MRPS35,RBM7,RPS14,ZNF207,HNRNPUL1,ZFML,UBE2I,RBM38 |
| iron-sulfur cluster binding | NUBP1,RSAD1,AOX3,AOX3L1,RPS3,NFS1,FDX1B,ISCUB,AIFM4,DPYDA.1 |
| metal ion binding | EXT1C,PPP1CA,ZNF497,ZNF404,CLCA3,KIT,SMG1,ARSG,TREX1,ATP2A2B |
| protein binding | AP5Z1,LSM8,FNIP1,ELOVL6,PI4K2A,CCL4,CDCP1,FHL2,RPLP2,MAGEF1 |
| protein disulfide oxidoreductase activity | GSTK1,TXN2,PTGES2,ERO1LB,CCS,CHCHD4,DNAJC10,TXN,GFER,SH3BGRL3 |
| electron carrier activity | TXNRD3,IDO1,TSTA3,AKR1B1,ACAD11,GSR,PRKRA,DERL3,DHDH,IDH3B |
Interacting Protein
GLRX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLRX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLRX3.
CIAPIN1;RGS20;PLSCR1;GRN
Resources
Research Area
Intracellular Kinases in the Akt PathwayPKC Isoforms
Wnt Intracellular Signaling
Intracellular Signaling Molecules in Angiogenesis
Natural Killer T (NKT) Cells
Related Services
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References
