GLRX
-
Official Full Name
glutaredoxin (thioltransferase) -
Overview
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimers disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011] -
Synonyms
GLRX;glutaredoxin (thioltransferase);GRX;GRX1;glutaredoxin-1;TTase-1;thioltransferase-1
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Flag
- GST
- Myc&DDK
Involved Pathway
GLRX involved in several pathways and played different roles in them. We selected most pathways GLRX participated on our site, such as Metabolism,Metabolism of nucleotides,Synthesis and interconversion of nucleotide di- and triphosphates, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLRX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synthesis and interconversion of nucleotide di- and triphosphates | AK8,DTYMK,GRX2,AK7,AK7A |
| Metabolism of nucleotides | ITPA,ADSL,DGUOK,NUDT1,DPYDA.1,AK7A,DCK,NUDT16,AK8,ADK |
| Metabolism | KCNC2,STARD5,PDK2,PDK4,LOC100686744,CYP26A1,ARSK,MED6,ALOX5B.2,FABP9 |
Protein Function
GLRX has several biochemical functions, for example, electron carrier activity,glutathione disulfide oxidoreductase activity,glutathione oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLRX itself. We selected most functions GLRX had, and list some proteins which have the same functions with GLRX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione disulfide oxidoreductase activity | GLRX2 |
| electron carrier activity | ETFDH,AIFM1,FDX1,AKR1C4,ACOXL,NCF1,CYBA,NDUFS3,CIAPIN1,GRX2 |
| protein N-terminus binding | NCOR2,SCFD1,NTSR1,RELA,EXOC5,NIPBL,ARF6,ERCC2,CSNK2A1,KCNIP2 |
Interacting Protein
GLRX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLRX here. Most of them are supplied by our site. Hope this information will be useful for your research of GLRX.
MMP23A;GOT2;CASP3;AQP5
Resources
Related Services
Related Products
References
