GLA
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Official Full Name
galactosidase, alpha -
Overview
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008] -
Synonyms
GLA;galactosidase, alpha;GALA;alpha-galactosidase A;melibiase;alpha-gal A;agalsidase alfa;alpha-D-galactosidase A;alpha-D-galactoside galactohydrolase 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Lactococcus lactis
- HEK293
- CHO
- Mammalian Cell
- E.coli
- Wheat Germ
- Insect Cell
- Human Cell
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- Myc&DDK
- Flag
- GST
- His&Fc&Avi
Involved Pathway
GLA involved in several pathways and played different roles in them. We selected most pathways GLA participated on our site, such as Galactose metabolism,Glycerolipid metabolism,Sphingolipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | GNS,ATP6V0C,TPP1,MCOLN1,CTSF,GNPTAB,MFSD8,CTSK,NAGPA,CTNS |
| Galactose metabolism | B4GALT2,GALE,AKR1B8,AKR1B10,UGP2,B4GALT1,PFKL,aLA,GAA,AKR1B1L |
| Glycerolipid metabolism | GLYCTK,LPIN1,PPAP2A,GPAM,PNLIPRP2,PNLIP,PNPLA3,GK,LIPC,LCLAT1 |
| Sphingolipid metabolism | SMPD1,ARSD,GAL3ST1A,NEU2,FA2H,UGT8,R05D11.9,GDF1,ARSH,CERS1 |
| Glycosphingolipid biosynthesis - globo series | B3GALT5,A4GALT,FUT1,HEXB,FUT2,ST8SIA1,FUT9,FUT9A,NAGA,HEXA |
Protein Function
GLA has several biochemical functions, for example, alpha-galactosidase activity,catalytic activity,galactoside binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLA itself. We selected most functions GLA had, and list some proteins which have the same functions with GLA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-galactosidase activity | NAGA |
| protein homodimerization activity | ATPIF1A,DAPK3,CADM2A,CRTAM,S100A10,BNIP3L,NR6A1A,HOMER2,SLC4A1,CPNE1 |
| catalytic activity | DBH,RAG1,MDH1AA,PPM1NB,SCP2A,NANSA,PHKA1,AGXTB,HSD17B6,PPM1DA |
| protein binding | PMF1,NAA11,PDS5B,GAN,ATF3,SLC4A4,HYPM,ABI3,KLF11,POLR1A |
| galactoside binding | LGALS3L,LGALS1L1,LGALS2A,LGALS2B,GLB1,LGALS9L1,LGALS2 |
| hydrolase activity | CTDNEP1,USP12A,AADACL4,SPAG1,EAR5,PPTC7A,GZME,PRSS59.2,NUDT3B,ZRANB3 |
| receptor binding | NPPC,RND1,NRXN1,LAMA1,TRIM24,CD276,AMH,LPL,HAND2,UCN2 |
Interacting Protein
GLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLA here. Most of them are supplied by our site. Hope this information will be useful for your research of GLA.
OTUD4;GABARAP;Rc3h2;Rc3h1
Resources
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References
- Rutkowska, J; Bialek, M; et al. Differentiation of geographical origin of cream products in Poland according to their fatty acid profile. FOOD CHEMISTRY 178:26-31(2015).
- Nahar-Gohad, P; Gohad, N; et al. Rat Aortic Smooth Muscle Cells Cultured on Hydroxyapatite Differentiate into Osteoblast-Like Cells via BMP-2-SMAD-5 Pathway. CALCIFIED TISSUE INTERNATIONAL 96:359-369(2015).
