GK
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Official Full Name
Glycerol Kinase -
Overview
Glycerol kinase catalyzes the formation of glycerol 3 phosphate from ATP and glycerol. Dihydroxyacetone and L glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. NB - Glycerol kinase obtained from Cellulomonas spp has an observed molecular weight of 128kDa. Glycerol kinase is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis -
Synonyms
ATP glycerol 3 phosphotransferase;ATP:glycerol 3 phosphotransferase;ATP:glycerol 3-phosphotransferase;GK;GK1;GKD;GLPK;Glycerokinase;Glycerol kinase;Glycerol kinase deficiency;OTTHUMP00000023108;OTTHUMP00000023109;OTTHUMP00000215321;D930012N15Rik
Recombinant Proteins
- Human
- Mouse
- E.coli
- Human herpesvirus 2
- Human Herpesvirus 1
- EHV1
- VZV
- Suid herpesvirus 1
- Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus)
- Gallid herpesvirus 2
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GK involved in several pathways and played different roles in them. We selected most pathways GK participated on our site, such as Glycerolipid metabolism,Metabolic pathways,PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | DGKZ,AGPAT9L,MOGAT1,TAE1,PNLIPRP3,AKR1B1,MBOAT2B,MGLL,AGPAT5,AKR1A1B |
| PPAR signaling pathway | PPARA,CYP4A12A,SLC27A1A,ACSL5,ACOX3,ACSL4B,PPARD,PPARDB,ILK,SCD5 |
| Metabolic pathways | POLR1D,NDST4,LPCAT2,COX5AA,POLR1C,FPGT,UGP2A,HSD3B1,POC1B-GALNT4,TDO2B |
Protein Function
GK has several biochemical functions, for example, ATP binding,glycerol kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GK itself. We selected most functions GK had, and list some proteins which have the same functions with GK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycerol kinase activity | GK2,GK5 |
| ATP binding | DDX53,ULK3,ORC5,TTBK2,FLT1,EPHA8,ATP2A2,H1FNT,DDX27,UHMK1 |
| protein binding | UCKL1,RING1,ALOX12B,RUNX2,DNAJA2,TRAIP,GOLM1,RUVBL2,BRCC3,COL1A2 |
Interacting Protein
GK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GK here. Most of them are supplied by our site. Hope this information will be useful for your research of GK.
Resources
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References
- Sicurella, M; Nicoli, F; et al. An Attenuated Herpes Simplex Virus Type 1 (HSV1) Encoding the HIV-1 Tat Protein Protects Mice from a Deadly Mucosal HSV1 Challenge. PLOS ONE 9:-(2014).
- Jambunathan, N; Chouljenko, D; et al. Herpes Simplex Virus 1 Protein UL37 Interacts with Viral Glycoprotein gK and Membrane Protein UL20 and Functions in Cytoplasmic Virion Envelopment. JOURNAL OF VIROLOGY 88:5927-5935(2014).
