GJC1
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Official Full Name
gap junction protein, gamma 1, 45kDa -
Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008] -
Synonyms
GJC1;gap junction protein, gamma 1, 45kDa;CX45;GJA7;gap junction gamma-1 protein;connexin 45;connexin-45;gap junction alpha-7 protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Rat
- Dog
- Cricetulus griseus
- Bovine
- Mus musculus
- Sus scrofa (Pig)
- Mesocricetus auratus
- zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GJC1 involved in several pathways and played different roles in them. We selected most pathways GJC1 participated on our site, such as Calcium Regulation in the Cardiac Cell,Electric Transmission Across Gap Junctions,Gap junction assembly, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Gap junction assembly | CX27.5,GJA8,GJD3,GJB4,GJB5,GJB2,GJB3,CX30.3,GJB7,GJA4 |
Gap junction trafficking | CX27.5,CX30.3,GJD3,GJB4,MYO6,GJA8,DAB2,GJB5,MYO6B,GJB2 |
Transmission across Electrical Synapses | PANX1,PANX1A,GJA10,PANX2,PANX1B |
Neuronal System | KCNC4,SYT1A,PANX2,KCNC1,KCNA1,KCNA10,KCNC2,KCNK16,KCNMB2,PANX1B |
Calcium Regulation in the Cardiac Cell | GNB5B,GJB5,CX27.5,ADRB1,RGS4,CX30.3,RGS17,RGS19,ADRB3,RGS20 |
Gap junction trafficking and regulation | GJB5,GJB2,MYO6A,GJB4,GJA4,DAB2,GJB3,CX27.5,CX30.3,MYO6B |
Electric Transmission Across Gap Junctions | PANX1A,GJA10,PANX1B,PANX1,PANX2 |
Membrane Trafficking | PREB,GJB5,TMED2,CNIH3,DTNBP1B,PICALMA,SNF8,DNASE2,SNX9A,TRAPPC2 |
Protein Function
GJC1 has several biochemical functions, for example, gap junction channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GJC1 itself. We selected most functions GJC1 had, and list some proteins which have the same functions with GJC1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ion channel activity | KCNB2,FXYD6L,TRPN1,P2RX4B,CLCN4-2,TRPV2,TRPC2B,GRIN1A,TRPC2,GABRA6A |
gap junction channel activity | GJB2,CX23,GJA10,GJA8,GJC2,GJD3,CX43,CX52.6,PANX2,GJA1 |
Interacting Protein
GJC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJC1.
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References
- Sohl, G; Joussen, A; et al. Expression of connexin genes in the human retina. BMC OPHTHALMOLOGY 10:-(2010).