GJA1
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Official Full Name
gap junction protein, alpha 1, 43kDa -
Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq, Jul 2008] -
Synonyms
GJA1;gap junction protein, alpha 1, 43kDa;HSS;CMDR;CX43;GJAL;ODDD;AVSD3;HLHS1;DFNB38;gap junction alpha-1 protein;connexin 43;connexin-43;gap junction 43 kDa heart protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- Chicken
- Chlorocebus Aethiops
- Dog
- Mus musculus
- Bovine
- Sus scrofa (Pig)
- Xenopus laevis
- Oryctolagus cuniculus (Rabbit)
- Macaca fascicularis
- Ursus americanus (American black bear) (Euarctos americanus)
- Erinaceus europaeus (Western European hedgehog)
- zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- Yeast
- HEK293F
- E.coli expression system
- His
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GJA1-350H |
Recombinant Human GJA1 protein, His-tagged
|
E.coli | Human | His | Ser244~Ile382 | |
| GJA1-893M | Recombinant Mouse GJA1 protein, His-tagged | E.coli | Mouse | His | Ser180-Ile382 | |
| GJA1-1857R | Recombinant Rhesus monkey GJA1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
|
| GJA1-2545R | Recombinant Rat GJA1 Protein | Mammalian Cell | Rat | His |
|
|
| Gja1-351M | Recombinant Mouse Gja1 Protein, His-tagged | E.coli | Mouse | His | Ser180~Ile382 |
|
| Gja1-352R | Recombinant Rat Gja1 Protein, His-tagged | E.coli | Rat | His | Ser180~Ile382 |
|
| GJA1-545C | Recombinant Cynomolgus GJA1 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
|
|
| GJA1-6155C | Recombinant Chicken GJA1 | Mammalian Cell | Chicken | His |
|
|
| GJA1-6368M | Recombinant Mouse GJA1 Protein | Mammalian Cell | Mouse | His |
|
|
| GJA1-5923HCL | Recombinant Human GJA1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Gja1-1310M | Recombinant Mouse Gja1 protein, His&Myc-tagged | HEK293 | Mouse | His&Myc | 232-382aa |
|
| GJA1-1312H | Recombinant Human GJA1 protein, His-tagged | HEK293 | Human | His | 233-382aa |
|
| GJA1-1677R | Recombinant Rhesus Macaque GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| GJA1-1677R-B | Recombinant Rhesus Macaque GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| GJA1-2081H | Recombinant Human GJA1 Protein (Phe232-Ile382), N-His tagged | E.coli | Human | His | Phe232-Ile382 |
|
| GJA1-2201R | Recombinant Rat GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| GJA1-2201R-B | Recombinant Rat GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
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| GJA1-2204H | Recombinant Human GJA1 Protein, His-tagged | E.coli | Human | His | Ser180-Ile382 |
|
| GJA1-2221H | Recombinant Human GJA1 protein, His-tagged | Insect Cell | Human | His | 233-382aa |
|
| Gja1-2222M | Recombinant Mouse Gja1 protein, His&Myc-tagged | Insect Cell | Mouse | His&Myc | 232-382aa |
|
| GJA1-290C | Recombinant Cynomolgus Monkey GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
|
|
| GJA1-290C-B | Recombinant Cynomolgus Monkey GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
|
||
| GJA1-2962H | Recombinant Human GJA1 protein, His-tagged | E.coli | Human | His | 233-382aa |
|
| GJA1-3569M | Recombinant Mouse GJA1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| GJA1-3569M-B | Recombinant Mouse GJA1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| Gja1-5414M | Recombinant Mouse Gja1 protein, His-Myc-tagged | Yeast | Mouse | His&Myc | 232-382aa |
|
| Gja1-951M | Recombinant Mouse Gja1 Protein, His-tagged | HEK293F | Mouse | His | Ser244-Ile382 |
|
| RFL10056HF | Recombinant Full Length Human Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (1-382) |
|
| RFL11577CF | Recombinant Full Length Chlorocebus Aethiops Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Chlorocebus Aethiops | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL11994RF | Recombinant Full Length Rat Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL15966GF | Recombinant Full Length Chicken Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length of Mature Protein (2-381) |
|
| RFL16814CF | Recombinant Full Length Dog Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Dog | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL23029MF | Recombinant Full Length Mouse Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (1-382) |
|
| RFL25501BF | Recombinant Full Length Bovine Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length of Mature Protein (2-383) |
|
| RFL28095SF | Recombinant Full Length Pig Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Sus scrofa (Pig) | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL2841XF | Recombinant Full Length Xenopus Laevis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Xenopus laevis | His | Full L. Full Length of Mature Protein (2-379) |
|
| RFL32091OF | Recombinant Full Length Rabbit Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Oryctolagus cuniculus (Rabbit) | His | Full L. Full Length of Mature Protein (1-382) |
|
| RFL33951MF | Recombinant Full Length Macaca Fascicularis Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Macaca fascicularis | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL34047UF | Recombinant Full Length Ursus Americanus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Ursus americanus (American black bear) (Euarctos americanus) | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL35560EF | Recombinant Full Length Erinaceus Europaeus Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | Erinaceus europaeus (Western European hedgehog) | His | Full L. Full Length of Mature Protein (2-382) |
|
| RFL8003DF | Recombinant Full Length Danio Rerio Gap Junction Alpha-1 Protein(Gja1) Protein, His-Tagged | E.coli expression system | zebrafish | His | Full L. Full Length of Mature Protein (2-381) |
|
Involved Pathway
GJA1 involved in several pathways and played different roles in them. We selected most pathways GJA1 participated on our site, such as Gap junction,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with GJA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNB1,ITGA7,ACTB,ACTN2,SGCD,SGCA,CACNA2D1,ITGA3,ACTN4,ITGB3 |
| Gap junction | GRB2A,PDGFRA,TUBB2,TUBA4A,GNAI2B,CSNK1DB,HTR2CL1,HTR2C,MAPK3,GNA11B |
Protein Function
GJA1 has several biochemical functions, for example, PDZ domain binding,SH3 domain binding,connexin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GJA1 itself. We selected most functions GJA1 had, and list some proteins which have the same functions with GJA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| connexin binding | CNSTB,GJA5,CNST,CXADR,CAV3 |
| SH3 domain binding | EVLB,SH3BP1,PLSCR1,SHANK3,NCKIPSD,PTTG1,PTTG2,USP8,SH3BP5B,CYBA |
| protein binding | ADRB1,CTSL2,ESR1,ANTXR1,C2orf51,ZFP488,ACAN,CDK7,EIF4A1,EIF2S2 |
| gap junction channel activity | CX52.6,CX30.3,CX23,GJB3,GJA8,GJC2,PANX2,CX43,GJA10,GJD3 |
| PDZ domain binding | ATP2B1A,PTEN,PROSAPIP1,Fzd4,ATP2B3B,KIDINS220B,PLEKHA1,CRIPT,CIT,GRIA1 |
| gap junction channel activity involved in cardiac conduction electrical coupling | GJA5 |
| signal transducer activity | CCR1L1,IL1RAP,GNAZ,GNG5,TAAR10D,PTGER4A,PLCD3,OLFR494,PKP1,GNA13 |
| ion transmembrane transporter activity | SFXN5B,TRPV2,SFXN5A,S100A6,PLP2,SFXN2,SFXN3,SFXN4,SFXN1,LASP1 |
Interacting Protein
GJA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJA1.
TJP1;CSK;DSC2;TFCP2;SRC
Resources
Research Area
Uptake and Transport Molecules on Endothelial CellsGlial Lineage Markers
Breast Cancer Stem Cell Markers
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References
- Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).
- Choudhury, A; Khole, VV; et al. HSP90 Antibodies: A Detrimental Factor Responsible for Ovarian Dysfunction. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY 70:372-385(2013).
