GIT2
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Official Full Name
G protein-coupled receptor kinase interacting ArfGAP 2 -
Overview
G protein-coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT1 and GIT2) are highly conserved, ubiquitous scaffold proteins involved in localized signaling to help regulate focal contact assembly and cytoskeletal dynamics. GIT proteins contai -
Synonyms
GIT2;G protein-coupled receptor kinase interacting ArfGAP 2;G protein coupled receptor kinase interactor 2;ARF GTPase-activating protein GIT2;KIAA0148;ARF GAP GIT2;GRK-interacting protein 2;G protein-coupled receptor kinase-interactor 2;cool-assoc
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GIT2 involved in several pathways and played different roles in them. We selected most pathways GIT2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CHMP2A,WASLA,IL2RGA,CCR5,WASH,BIN1B,EPS15,H2-Q10,RHOAD,GIT2A |
Protein Function
GIT2 has several biochemical functions, for example, GTPase activator activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GIT2 itself. We selected most functions GIT2 had, and list some proteins which have the same functions with GIT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ICAM3,CIB1,THOC5,SNX1,LMNA,AACS,TBL1XR1,HSP90B1,TRIM69,NLGN4X |
| metal ion binding | TGM2B,ZNF691,ZNF397,MOBKL2B,CISD2,CYP2K18,MORC2B,ZFP292,ICN,NDUFS1 |
| GTPase activator activity | TBC1D3,RABEP2,ARHGDIG,TBC1D14,GRTP1A,RAP1GAP,RGS6,GDI2,RGS3A,LLGL2 |
| protein complex binding | PLK2,INS2,TRAF2,PFKP,CDK2,MLC1,NCKAP1,TULP2,TUBB,UQCRC2 |
Interacting Protein
GIT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GIT2.
IKBKG;PXN;TNIP1;PAK2;TRAF1;TSN;Arhgef7;KRT18
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References
- Esteves, LM; Bulhoes, SM; et al. Human Leptospirosis: Seroreactivity and Genetic Susceptibility in the Population of Sao Miguel Island (Azores, Portugal). PLOS ONE 9:-(2014).
- Brunner, PM; Koszik, F; et al. Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)(+) dendritic cells and macrophages. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 132:1184-+(2013).
