GGA1
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Official Full Name
ADP-ribosylation factor binding protein -
Overview
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GGA1;ADP-ribosylation factor binding protein
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293T
- HEK293
- E. coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GGA1 involved in several pathways and played different roles in them. We selected most pathways GGA1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | CTSSB.1,AGA,CTSC,LAPTM5,MFSD8,PPT2,CTSZ,GLB1,SLC17A5,TCIRG1 |
Protein Function
GGA1 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GGA1 itself. We selected most functions GGA1 had, and list some proteins which have the same functions with GGA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MID1,MRPL12,ZNF239,SPSB4,SAFB2,STMN2,UBOX5,MMP14,PIF1,SNAP23 |
| molecular_function | TUBB6,VMN1R130,SCGB2A2,RPRMA,SLC35F3A,C10orf116,TMEM26B,TP53I11B,IKZF2,CACFD1 |
Interacting Protein
GGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGA1.
RABEP1;IGF2R;SORT1;RNF11;DTNB
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