GFM2
-
Official Full Name
G elongation factor, mitochondrial 2 -
Overview
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in at least three transcript variants encoding distinct isoforms. -
Synonyms
GFM2;G elongation factor, mitochondrial 2;ribosome-releasing factor 2, mitochondrial;EFG2;FLJ21661;MSTP027;mitochondrial elongation factor G2;elongation factor G 2, mitochondrial;mitochondrial ribosome recycling factor 2;RRF2;MRRF2;hEFG2;MST02
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
- His&T7
- Myc&DDK
Involved Pathway
GFM2 involved in several pathways and played different roles in them. We selected most pathways GFM2 participated on our site, such as Mitochondrial translation,Mitochondrial translation termination,Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation termination | MRPS28,MRPS31,MRRF,MRPL50,MRPS34,MRPS24,MRPL37,CHCHD1,MRPL40,MRPL54 |
| Mitochondrial translation | MRPL46,MRPL50,MRPS22,MRPL54,MRPL49,GADD45GIP1,MRPL28,MRPL48,GFM1,MRPL47 |
| Organelle biogenesis and maintenance | CCDC41,TTC30B,CNGA5,PKD1,MRPS34,IFT81,MRPL47,MRPL10,NPHP4,GABPA |
Protein Function
GFM2 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFM2 itself. We selected most functions GFM2 had, and list some proteins which have the same functions with GFM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | GNAO1,GNAV1,TUBA3D,RAB8A,GNAZ,TUBA1A,MX1,EEF2A.1,RAB22A,RAB5AA |
| GTP binding | RAB1BB,GMPPB,GNAI3,GNAO1B,RAB2B,AGAP1,RALAA,RALB,TUBA1B,GTPBP4 |
| NOT translation elongation factor activity | EFTUD2 |
| protein binding | ADCYAP1,RAB38,TACR1,CPSF6,TIPIN,ARHGAP24,FOXO3,UBE2V1,PTPRS,CCT2 |
Interacting Protein
GFM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFM2.
TRIM27;VPS52;BANP;TRIM9;SMAD2;SLX4
Resources
Related Services
Related Products
References
