GDAP1
-
Official Full Name
ganglioside-induced differentiation-associated protein 1 -
Overview
This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
GDAP1;ganglioside-induced differentiation-associated protein 1;Charcot Marie Tooth neuropathy 4A , CMT4A;CMT4;Ganglioside induced differentiation associated protein 1;GDAP1_HUMAN;OTTHUMP00000226874;OTTHUMP00000226875;Charcot-Marie-Tooth neuropathy 4A;ganglioside differentiation associated protein 1;CMT4A;CMTRIA
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Mus musculus
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GDAP1 involved in several pathways and played different roles in them. We selected most pathways GDAP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GDAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GDAP1 has several biochemical functions, for example, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDAP1 itself. We selected most functions GDAP1 had, and list some proteins which have the same functions with GDAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTA1,MGST3,MGST2,GSTM2,GDAP1L1,GSTA4,GSTM5,GSTT1B,GSTM4,GSTT1 |
Interacting Protein
GDAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDAP1.
Prkaa1;Tmed10
Resources
Related Services
Related Products
References
- Hsu, AK; Rosow, DE; et al. Familial congenital bilateral vocal fold paralysis: A novel gene translocation. INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 79:323-327(2015).
- Del Amo, VL; Seco-Cervera, M; et al. Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy. HUMAN MOLECULAR GENETICS 24:21-36(2015).
