GATM
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Official Full Name
glycine amidinotransferase (L-arginine:glycine amidinotransferase) -
Overview
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. -
Synonyms
GATM;glycine amidinotransferase (L-arginine:glycine amidinotransferase);glycine amidinotransferase, mitochondrial;AGAT;mitochondrial;AT;GATM_HUMAN;Glycine amidinotransferase;L-arginine:glycine amidinotransferase;Transamidinase
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
GATM involved in several pathways and played different roles in them. We selected most pathways GATM participated on our site, such as Glycine, serine and threonine metabolism,Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | INPP5KA,UGT1A7,TREH,HPDB,ASS1,ADSL,AGXT,TRIT1,NT5C1B-RDH14,SMPD1 |
| Arginine and proline metabolism | ALDH3A2A,ABP1,HOGA1,GOT2A,CKM,NOS1,CKMT1,NOS2,ALDH2.1,AZIN2 |
| Glycine, serine and threonine metabolism | AMT,DAO.2,CBS,BPGM,PSPH,SHMT2,BHMT,DAO.1,SHMT1,AGXTA |
Protein Function
GATM has several biochemical functions, for example, glycine amidinotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GATM itself. We selected most functions GATM had, and list some proteins which have the same functions with GATM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
GATM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATM here. Most of them are supplied by our site. Hope this information will be useful for your research of GATM.
Gatm;CYP2E1;ytrB;y2173_bacan;yjhB;aspC;q99ib8-pro_0000045598
Resources
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References
- Wang, FS; Cao, M; et al. Seasonal variation of CO2 diffusion flux from a large subtropical reservoir in East China. ATMOSPHERIC ENVIRONMENT 103:129-137(2015).
- Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
