GAS8
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Official Full Name
growth arrest-specific 8 -
Overview
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. -
Synonyms
GAS8;growth arrest-specific 8;GAS11, growth arrest specific 11;growth arrest-specific protein 8;Growth arrest specific protein 8;MGC138326;GAS 11;GAS 8;GAS11;Growth arrest specific 11;Growth arrest specific 8;Growth arrest specific protein 11;GAS-8;GAS-11;growth arrest-specific 11;growth arrest-specific protein 11
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
GAS8 involved in several pathways and played different roles in them. We selected most pathways GAS8 participated on our site, such as Activation of SMO,Hedgehog on state,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hedgehog on state | KIF7,IFT172,MKS1,EVC2,IQCE,CDON,CDC73,SPOP,DZIP1,BOC |
| Signaling by Hedgehog | BOC,DISP2,NOTUM1A,EVC2,BBS13,TULP3,IQCE,RPGRIP1L,WDR19,GPR161 |
| Activation of SMO | EVC,CSNK1A1,CDON,SETD6,ADRBK1,EVC2,KIF3A,EFCAB7,BOC,IQCE |
| Signal Transduction | PTHLHA,WDR35,CRABP2A,TAS2R16,PPEF1,OPN4.1,RDH14B,QRFPR,ARHGEF1A,MYO7A |
Protein Function
GAS8 has several biochemical functions, for example, Rab GTPase binding,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by GAS8 itself. We selected most functions GAS8 had, and list some proteins which have the same functions with GAS8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | GLOD5,C21orf2,MXRA8A,UBTD1A,ANKRD52A,FAM176A,RASSF7B,MAMLD1,ITPRIPL2,NUPR1 |
| Rab GTPase binding | ANXA2,TMEM127,NDRG1,ANKRD27,RUSC2,ZFP652,CCDC64,MICALL2,MYO5A,ALS2 |
Interacting Protein
GAS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAS8.
CIAO1;IQCB1
Resources
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References
- Horani, A; Brody, SL; et al. CCDC65 Mutation Causes Primary Ciliary Dyskinesia with Normal Ultrastructure and Hyperkinetic Cilia. PLOS ONE 8:-(2013).
- Evron, T; Philipp, M; et al. Growth Arrest Specific 8 (Gas8) and G Protein-coupled Receptor Kinase 2 (GRK2) Cooperate in the Control of Smoothened Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 286:27676-27686(2011).
