Gar1
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Official Full Name
GAR1 GAR1 ribonucleoprotein homolog (yeast) [ Homo sapiens ] -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. -
Synonyms
GAR1 ribonucleoprotein homolog (yeast);14264;Ensembl:ENSG00000109534;H/ACA ribonucleoprotein complex subunit 1;snoRNP protein GAR1;nucleolar protein family A member 1;nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs);NOLA1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GAR1-13156H | Recombinant Human GAR1, GST-tagged | E.coli | Human | GST | 1-217a.a. | |
| GAR1-11210Z | Recombinant Zebrafish GAR1 | Mammalian Cells | Zebrafish | His |
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| GAR1-2478R | Recombinant Rat GAR1 Protein | Mammalian Cells | Rat | His |
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| GAR1-6209M | Recombinant Mouse GAR1 Protein | Mammalian Cells | Mouse | His |
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| GAR1-6021HCL | Recombinant Human GAR1 293 Cell Lysate | HEK293 | Human | Non |
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| GAR1-2134R | Recombinant Rat GAR1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GAR1-2134R-B | Recombinant Rat GAR1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GAR1-3468M | Recombinant Mouse GAR1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GAR1-3468M-B | Recombinant Mouse GAR1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Gar1-4456M | Recombinant Mouse Gar1 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| GAR1-5978H | Recombinant Human GAR1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
Gar1 involved in several pathways and played different roles in them. We selected most pathways Gar1 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gar1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | MPHOSPH10,RRP7A,IMP3,NHP2,NXT2,PWP2,GNL3L,NXF1,cka1,POP5 |
Protein Function
Gar1 has several biochemical functions, for example, cation channel activity,poly(A) RNA binding,telomerase RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gar1 itself. We selected most functions Gar1 had, and list some proteins which have the same functions with Gar1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NOL6,SSB,GTPBP4,NSUN5,MRM1,SRPR,DARS,CCDC9,HIST2H4A,MRPL11 |
| telomerase RNA binding | HNRNPU,WRAP53,HNRNPC,NHP2,NOP10,DKC1,PINX1,TERT |
| cation channel activity | PKD2L1,TRPM1,GRIN2A,ASIC1A,P2RX1,CALHM2,CALHM3,TRPM1A,FAM26E,GRIN3B |
Interacting Protein
Gar1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gar1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gar1.
SMN1;DKC1;USP10;USP39;Nhp2l1;ssdna_dtdg;TAF1;FAAP20;CEP89;PRMT5;GABARAP;FN1;ALB;MAPT;MNDA;CLNS1A;RPL27;HSPG2
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References
- Chauvin, C; Koka, V; et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. ONCOGENE 33:474-483(2014).
- von Stedingk, K; Koster, J; et al. snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis. TRANSLATIONAL ONCOLOGY 6:447-U142(2013).
