Gabrb2
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 -
Synonyms
GABRB2;gamma-aminobutyric acid (GABA) A receptor, subunit beta 2;gamma-aminobutyric acid receptor subunit beta-2;GABA;GABA(A) receptor subunit beta-2;Gamma-aminobutyric-acid receptor subunit beta-2;OTTMUSP00000006670;gamma-aminobutyric acid receptor beta-2 subunit;gamma-aminobutyric acid A receptor, subunit beta 2;gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2;Gabrab2;Gabrb-2;AI834970;C030002O17Rik;C030021G16Rik
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
Gabrb2 involved in several pathways and played different roles in them. We selected most pathways Gabrb2 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabrb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | PRKCA,NRAS,GNGT2,SLC6A4,ALOX12,GNB3,HRAS,HTR1B,CYP2C37,GNGT1 |
| Retrograde endocannabinoid signaling | GNB4,NAPEPLD,GABRA6,GNG13,SLC17A7,PRKCA,GRIA2,MAPK8,GNG8,ABHD6 |
| GABAergic synapse | PRKCA,GNAI2,SLC38A5,HAP1,GAD1,PRKACA,SLC38A1,GABRR1,GABRA2,GABRA6 |
| Neuroactive ligand-receptor interaction | PRSS1,PTGER3,GABRA5,DRD7,GRIK2,GABRR2,RXFP1,AGTR1B,F2RL1.1,GABRB3 |
| Nicotine addiction | GABRG1,GABRP,GRIN2D,GABRE,GRIN2C,GABRA1,GABRR2,GRIN3A,GABRG2,GABRB1 |
Protein Function
Gabrb2 has several biochemical functions, for example, GABA-A receptor activity,contributes_to chloride channel activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabrb2 itself. We selected most functions Gabrb2 had, and list some proteins which have the same functions with Gabrb2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GABA-A receptor activity | GABRR2A,GABRA1,GABRG2,GABRR3,GABRB3,GABRR1,GABRE,GABRD,GABRA6A,GABRB1 |
| inhibitory extracellular ligand-gated ion channel activity | GABRG1,GABRA2,GABRG3,GABRG2,GABRA6,GABRE,GABRA6A,GABRA5,GABRA3,GABRA1 |
| contributes_to chloride channel activity | BEST2,GABRR2A,GABRQ,GABRR2,BEST1,BEST4,GABRB3,BSND,GABRZ,GABRB1 |
| chloride channel activity | CFTR,CLCN3,SLC26A11,CLIC4,CLCA5,GABRA3,CLCA4,CLCA1,GABRA1,FXYD1 |
| contributes_to extracellular ligand-gated ion channel activity | GABRR3A,GABRR2,GABRZ,GABRQ,GABRB1,GABRR2A,GABRB3 |
Interacting Protein
Gabrb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gabrb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gabrb2.
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References
- Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).
- Zhang, QR; Long, Q; et al. AprioriGWAS, a New Pattern Mining Strategy for Detecting Genetic Variants Associated with Disease through Interaction Effects. PLOS COMPUTATIONAL BIOLOGY 10:-(2014).
