GABRB1
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, beta 1 -
Overview
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. -
Synonyms
GABRB1;gamma-aminobutyric acid (GABA) A receptor, beta 1;gamma-aminobutyric acid receptor subunit beta-1;GABA(A) receptor;beta 1;GABA(A) receptor, beta 1;GABA(A) receptor subunit beta-1
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GABRB1-13097H | Recombinant Human GABRB1, His-tagged | E.coli | Human | His | 330-440a.a. | |
| GABRB1-2448R | Recombinant Rat GABRB1 Protein | Mammalian Cells | Rat | His |
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| GABRB1-6149M | Recombinant Mouse GABRB1 Protein | Mammalian Cells | Mouse | His |
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| GABRB1-6062HCL | Recombinant Human GABRB1 293 Cell Lysate | HEK293 | Human | Non |
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| GABRB1-1548H | Recombinant Human GABRB1 Protein, His-tagged | E.coli | Human | His | His26-Tyr245 |
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| GABRB1-2104R | Recombinant Rat GABRB1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GABRB1-2104R-B | Recombinant Rat GABRB1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GABRB1-3430M | Recombinant Mouse GABRB1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GABRB1-3430M-B | Recombinant Mouse GABRB1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GABRB1-4645H | Recombinant Human GABRB1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
GABRB1 involved in several pathways and played different roles in them. We selected most pathways GABRB1 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nicotine addiction | GRIN2A,GABRP,GRIA2,GRIN2D,GABRG2,GABRB2,GRIA3,GABRG1,GABRA6,GABRQ |
| Retrograde endocannabinoid signaling | GNG4,MAPK12,GABRE,GNAO1,MAPK8,GABRQ,PLCB4,GNG11,GNGT1,PRKACB |
| GABAergic synapse | GABARAPL2,GABRA4,SLC6A13,GNG10,GABRG1,SLC38A3,GABRA1,GAD2,GABRB2,SLC6A1 |
| Neuroactive ligand-receptor interaction | TAAR1,GLRA3,OXTR,S1PR4,GLRBB,HTR1AB,ADORA1,GABRA3,MTNR1BB,P2RY2 |
| Serotonergic synapse | GNG5,PRKCB,CYP2C37,TPH1,GABRB2,ALOX12,HTR6,CYP2J6,GNB3,GNGT1 |
Protein Function
GABRB1 has several biochemical functions, for example, GABA receptor binding,GABA-A receptor activity,contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRB1 itself. We selected most functions GABRB1 had, and list some proteins which have the same functions with GABRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to chloride channel activity | GABRR2,GABRZ,GABRB2,GABRB3,BEST3,BEST2,BEST4,GABRQ,GABRR3A,BSND |
| ligand-gated ion channel activity | CNGA3,CHRNB1,ZACN,TRPA1B,CHRNB2,TRPA1A,CHRNB4,CLCA2,CHRNA5,CLCA5 |
| GABA receptor binding | AKAP5,GABRG1,PLCL1,GABRA5,PPP2CA,ARFGEF2,MAF1,GABARAPL2,GABARAPL1,GABARAP |
| contributes_to extracellular ligand-gated ion channel activity | GABRB3,GABRQ,GABRR3A,GABRZ,GABRR2,GABRR2A,GABRB2 |
| GABA-A receptor activity | GABRZ,GABRA6A,GABRB3,GABRD,GABRR2A,GABRB2,GABRE,GABRR1,GABRG2,GABRR3 |
Interacting Protein
GABRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRB1.
FKBP5;NEUROD4;NOD1;q96be0_human
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References
- Zhu, B; Chen, CS; et al. The GABRB1 gene is associated with thalamus volume and modulates the association between thalamus volume and intelligence. NEUROIMAGE 102:756-763(2014).
- Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).
