GABPA
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Official Full Name
GA binding protein transcription factor, alpha subunit 60kDa -
Overview
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
GABPA;GA binding protein transcription factor, alpha subunit 60kDa;GA binding protein transcription factor, alpha subunit (60kD);GA-binding protein alpha chain;E4TF1 60;E4TF1A;human nuclear respiratory factor 2 subunit alpha;NFT2;NRF2;NRF2A;nucl
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GABPA involved in several pathways and played different roles in them. We selected most pathways GABPA participated on our site, such as Energy Metabolism,Mitochondrial biogenesis,Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Energy Metabolism | TFB1M,UCP2,UCP3,MEF2B,MYBBP1A,ESRRA,TFB2M,PPARGC1B |
| Mitochondrial biogenesis | POLG2,PPRC1,MTERF,PPARGC1B,TFB1M,ESRRA,TFB2M,GABPB1,POLRMT,C10orf2 |
| Organelle biogenesis and maintenance | KIF17,NPHP1,IFT20,TUFM,MRRF,DYNLL2B,IFT172,MRPL28,IFT43,MTIF3 |
| Myometrial Relaxation and Contraction Pathways | ATF5,RGS7,PKIB,CRHR1,IGFBP2,CRH,GPR182,RAMP3,RGS20,RGS10 |
| Transcriptional activation of mitochondrial biogenesis | POLRMT,GABPB1,MTERF,PPRC1,POLG2,C10orf2,TFB1M |
Protein Function
GABPA has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABPA itself. We selected most functions GABPA had, and list some proteins which have the same functions with GABPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PA2G4,CALCRL,MAPT,CCL4,ATPAF1,GDI1,PLEKHN1,BFSP2,PARN,IGF1R |
| DNA binding | HOXA11A,TBX5B,TCF15,ZNF566,HIST1H2BJ,ZBTB24,ZNF426,C17orf49,SAFB2,ZBTB6 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HAND1,MZF1,NKX2-5,MED8,MYC,ZNF562,MIXL1,ZNF664,IFI203,SMAD4 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MEOX2,PITX2,SMAD2,TFAM,CREB3,NFIA,NKX2-8,TBX20,GLIS2,SOX12 |
| transcription regulatory region DNA binding | ARID5B,SP1,ZFP161,RELA,RFX6,HIVEP3,SMAD7,SOX6,KDM1A,SMAD3 |
| chromatin binding | PYGO2,MED1,ZFP932,SOX10,GATA2A,JMJD5,LRWD1,ELK4,PHF21A,CHD8 |
| transcription factor activity, sequence-specific DNA binding | MEF2C,RARGB,HOXB5A,ZNF7,PRRX2,TAF6,RUNX2,HSF2,FOXO1A,SNAPC5 |
| protein heterodimerization activity | USF2,DDIT3,ITGA3,PDGFA,NEUROD2,TYRP1,PRPH,TFDP3,SMC4,ADIPOR2 |
| transcription coactivator activity | ABRA,SUPT7L,CITED2,NEUROD1,WNT3A,E4F1,FUS,NR2F1,PER2,SETD3 |
Interacting Protein
GABPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABPA here. Most of them are supplied by our site. Hope this information will be useful for your research of GABPA.
SP1;SP3;HCFC1;ADGRB2;PINX1;brca1_human_gene
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