FUCA2
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Official Full Name
fucosidase, alpha-L- 2, plasma -
Overview
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. -
Synonyms
FUCA2;fucosidase, alpha-L- 2, plasma;plasma alpha-L-fucosidase;dJ20N2.5;MGC1314;alpha-L-fucosidase 2;alpha-L-fucoside fucohydrolase 2;RP1-20N2.5
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FUCA2-1224Z | Recombinant Zebrafish FUCA2 | Mammalian Cell | Zebrafish | His |
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| FUCA2-2408R | Recombinant Rat FUCA2 Protein | Mammalian Cell | Rat | His |
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| FUCA2-28957TH | Recombinant Human FUCA2 | Wheat Germ | Human | Non | 467 amino acids |
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| FUCA2-679H | Recombinant Human fucosidase, alpha-L- 2, plasma, His-tagged | E.coli | Human | His | 29-467 a.a. |
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| FUCA2-6122HCL | Recombinant Human FUCA2 293 Cell Lysate | HEK293 | Human | Non |
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| FUCA2-1532H | Recombinant Human FUCA2 Protein, His-tagged | E.coli | Human | His | Glu81-Ile467 |
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| FUCA2-173HF | Recombinant Full Length Human FUCA2 Protein | In Vitro Cell Free System | Human | Full L. 467 amino acids |
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| FUCA2-2064R | Recombinant Rat FUCA2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FUCA2-2064R-B | Recombinant Rat FUCA2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| FUCA2-4262H | Recombinant Human FUCA2 protein, His&His-tagged | E.coli | Human | His | 29-467aa |
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| FUCA2-4545H | Recombinant Human FUCA2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FUCA2-4787H | Recombinant Human FUCA2 protein, GST-tagged | E.coli | Human | GST | 29-465aa |
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| FUCA2-5134HF | Recombinant Full Length Human FUCA2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 467 amino acids |
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Involved Pathway
FUCA2 involved in several pathways and played different roles in them. We selected most pathways FUCA2 participated on our site, such as Other glycan degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Other glycan degradation | NEU1,MANBA,NEU3.5,NEU3.1,ENG-1,MAN2B1,NEU3.3,ENGASE,NEU2,FUCA1 |
Protein Function
FUCA2 has several biochemical functions, for example, alpha-L-fucosidase activity,fucose binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FUCA2 itself. We selected most functions FUCA2 had, and list some proteins which have the same functions with FUCA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAD1L1,TDRD9,OAS3,A2M,FOXC2,SMURF2,SCNM1,CDKN2C,ADAMTSL3,ASCL4 |
| fucose binding | SELP,FUOM,FUCA1 |
| alpha-L-fucosidase activity | FUCA1.2,FUCA1,FUCA1.1 |
Interacting Protein
FUCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUCA2.
MEOX2;q9wmx2-pro_0000037548
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References
- Sobkowicz, AD; Gallagher, ME; et al. Modulation of expression in BEAS-2B airway epithelial cells of alpha-l fucosidase A1 and A2 by Th1 and Th2 cytokines, and overexpression of alpha-l-fucosidase 2. MOLECULAR AND CELLULAR BIOCHEMISTRY 390:101-113(2014).
- van Bergen, CAM; Verdegaal, EME; et al. Durable Remission of Renal Cell Carcinoma in Conjuncture with Graft versus Host Disease following Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion: Rule or Exception?. PLOS ONE 9:-(2014).
