FPR1
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Official Full Name
formyl peptide receptor 1 -
Overview
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation. -
Synonyms
FPR1;formyl peptide receptor 1;fMet-Leu-Phe receptor;FMLP;FPR;fMet Leu Phe receptor;FMLP Receptor;FMLPR;FPR 1;FPR receptor;FPR1_HUMAN;N formyl peptide chemoattractant receptor;N formyl peptide receptor;N formylpeptide chemoattractant receptor;N-formyl peptide receptor;N-formylpeptide chemoattractant receptor
Recombinant Proteins
- Human
- Mouse
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pongo Pygmaeus
- Mus musculus
- Pan troglodytes
- Macaca mulatta
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Flag&His
- Non
- GST
- GST&His
- GST&His&Myc
- Avi&Fc&His
Involved Pathway
FPR1 involved in several pathways and played different roles in them. We selected most pathways FPR1 participated on our site, such as Rap signaling pathway,Neuroactive ligand-receptor interaction,Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | TRPV1,AVPR2,CHRNA4B,TAAR12E,GABRA4,GABRA5,GRIA2,TRHRB,F2,TAAR14L |
| Staphylococcus aureus infection | HLA-DOB,ITGAM,MASP1,ITGAL,FCGR1A,FCGR3B,HLA-DQB1,MBL1,C2,FPR2 |
| Rap signaling pathway | ACTG1,VASP,ANGPT2,GNAO1,NGFR,FGFR2,MAP2K3,RHOA,MAPK3,MET |
Protein Function
FPR1 has several biochemical functions, for example, N-formyl peptide receptor activity,RAGE receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FPR1 itself. We selected most functions FPR1 had, and list some proteins which have the same functions with FPR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-formyl peptide receptor activity | FPR-RS6,FPR-RS3,FPR2,FPR-RS4 |
| protein binding | PTCH1,YY1,HMGB1,RBM12B,SYT6,MMP3,NOX1,RCOR3,CSTF2T,CHTOP |
| receptor activity | CADM3,NPC1,GRIN2BB,CD2,ITGAX,P2RY2,NLGN4X,TLR4,NLGN4B,NOTCH1 |
| RAGE receptor binding | S100A12,S100A4,HMGB1,S100A7,S100A8,HMGB2,S100A13,S100A9,S100B,S100P |
Interacting Protein
FPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FPR1.
MAPK13;ADRBK1;MAPK3;lcrD
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References
- Charest-Morin, X; Roy, C; et al. Pharmacological profile of a bifunctional ligand of the formyl peptide receptor(1) fused to the myc epitope. INTERNATIONAL IMMUNOPHARMACOLOGY 25:229-234(2015).
- Balderud, LZ; Murray, D; et al. Using the BioAssay Ontology for Analyzing High-Throughput Screening Data. JOURNAL OF BIOMOLECULAR SCREENING 20:402-415(2015).
