FOXC1
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Official Full Name
forkhead box C1 -
Overview
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] -
Synonyms
FOXC1;forkhead box C1;ARA;IGDA;IHG1;FKHL7;IRID1;RIEG3;FREAC3;FREAC-3;forkhead box protein C1;myeloid factor-delta;forkhead box C1 protein;forkhead-related activator 3;forkhead-related protein FKHL7;forkhead, drosophila, homolog-like 7;forkhead-related transcription factor 3;forkhead/winged helix-like transcription factor 7
Recombinant Proteins
- Mouse
- Chicken
- Human
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXC1-5980M | Recombinant Mouse FOXC1 Protein | Mammalian Cell | Mouse | His |
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| FOXC1-6564C | Recombinant Chicken FOXC1 | Mammalian Cell | Chicken | His |
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| Foxc1-7634M | Recombinant Mouse Foxc1 protein, His-tagged | E.coli | Mouse | His | Arg62~Lys186 |
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| FOXC1-6161HCL | Recombinant Human FOXC1 293 Cell Lysate | HEK293 | Human | Non |
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| FOXC1-3317M | Recombinant Mouse FOXC1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FOXC1-3317M-B | Recombinant Mouse FOXC1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FOXC1-4437H | Recombinant Human FOXC1 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
FOXC1 involved in several pathways and played different roles in them. We selected most pathways FOXC1 participated on our site, such as Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Heart Development | NKX2-5,NKX2,TBX20,BMP10,HEY1,HEY2,SMYD1,IRX4,FOXH1,TBX5 |
Protein Function
FOXC1 has several biochemical functions, for example, DNA binding,DNA binding, bending,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC1 itself. We selected most functions FOXC1 had, and list some proteins which have the same functions with FOXC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | SOX17,MAFF,MYOD1,PAX9,MYF6,NHLH1,EP300,IKZF3,FOXF2,CSRNP2 |
| sequence-specific DNA binding | HDAC2,RXRAB,MTPN,ZBTB4,HEY2,NFE2L2B,SREBF1,ARNTL,FOXI1,VENTX |
| RNA polymerase II regulatory region sequence-specific DNA binding | CREBBP,FERD3L,E2F7,EAF2,DBP,PHOX2A,LMO2,HES6,NFIL3,ZMYND11 |
| transcription regulatory region DNA binding | TBX16,HHEX,ZFP513,THRA,TP73,ZFP639,GATA4,DHX36,KCNA3,SIX1 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | PDX1,AHR,PAX3,POU3F1,NFATC1,USF1,JUN,RFX3,MITF,ATF2 |
| transcription factor activity, sequence-specific DNA binding | PRDM15,RNF4,SOX3,ETS1,CREB3L3A,ZFP37,RREB1,ATF4B2,MYCA,SMAD2 |
| transcription factor binding | TNFRSF10A,CCND1,SMARCA4,E2F1,MYOD1,DNMT1,TRIM6,SUFU,TFAP2A,MAPK1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXM1,TFE3A,ELF2B,FOXN1,ZNF18,SIM1B,HOXA13B,KLF11,TFAP2D,ZMYM5 |
| DNA binding | FOXI3A,ZFP654,C19orf40,HOXD13A,ISL2B,PDS5B,TFB1M,ZNF764,ALS2CR8,YBX1 |
Interacting Protein
FOXC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC1.
FLNA;PBX1;C1QBP;PITX2
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References
- Sadagopan, KA; Liu, GT; et al. Anirdia-Like Phenotype Caused by 6p25 Dosage Aberrations. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:524-528(2015).
- Yoshimura-Furuhata, M; Nishimura-Tadaki, A; et al. Renal Complications in 6p Duplication Syndrome: Microarray-Based Investigation of the Candidate Gene(s) for the Development of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) and Focal Segmental Glomerular Sclerosis (FSGS). AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:592-601(2015).
