FLNC
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Official Full Name
filamin C, gamma -
Overview
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
FLNC;filamin C, gamma;filamin C, gamma (actin binding protein 280) , FLN2;filamin-C;ABP 280;ABPL;actin binding protein 280;ABP L;Actin binding like protein;Filamin 2;Filamin C;Filamin C gamma;FLJ10186;FLN 2;FLN2;Gamma actin binding protein;Gamma filamin;Protein FLNc;FLN-C;filamin-2;ABP-280-like protein;ABP-L, gamma filamin;actin-binding-like protein;ABPA;MFM5;MPD4;ABP-280;ABP280A
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Chicken Gizzard
- His
- T7
- Avi
- Fc
- GST
- Non
Involved Pathway
FLNC involved in several pathways and played different roles in them. We selected most pathways FLNC participated on our site, such as MAPK signaling pathway,Focal adhesion,Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLNC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CACNA2D2,FGF14,GADD45B,HSPA1A,MAPKAPK2A,MAP2K4,MAPK8B,TRAF6,RAC3,PRKCB |
| Salmonella infection | PYCARD,RAC1B,IL-8,MYD88,RAB7,IFNGR1,RHOG,IL18,ROCK1,MAPK11 |
| Proteoglycans in cancer | ERBB3,RHOA,HPSE2,ROCK1,FZD1,PAK1,RPS6,WNT7A,TRP53,AKT1 |
| Focal adhesion | MYLK,MET,VEGFC,ELK1,PRKCA,RAPGEF1,MLCK2,MYL7,MYL9,RAF1 |
Protein Function
FLNC has several biochemical functions, for example, actin binding,actin filament binding,ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLNC itself. We selected most functions FLNC had, and list some proteins which have the same functions with FLNC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | PARK2,DMTN,LSP1,TPM2,FSCN2,ACTN3A,NRAP,WASF3B,FMN1,SCINLA |
| ankyrin binding | KCTD6,PLEC,SLC8A1,SPTBN1,KCNJ11,RHBG,RHCG,NRCAM,SCN5A,ATP1A1 |
| cytoskeletal protein binding | B4GALT1,RPH3AL,PACSIN3,CAPN2,ALDOA,ANXA2A,PACSIN1,ANXA2,TOR1A,ALDOB |
| actin filament binding | TMOD4,MYH11A,HAND2,MYO6,MYH9A,TRIOBPB,MYH3,MYH10,MYO18A,SPTA1 |
Interacting Protein
FLNC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLNC here. Most of them are supplied by our site. Hope this information will be useful for your research of FLNC.
Pcbp2;NPHP4;Grin1;Ywhae;Grin2b;Iqcb1;Rpgrip1l;Nphp1
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